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Risk Stratification of Uterine Smooth Muscle Tumors: The Role of Morphology, Immunohistochemistry, and Molecular Testing.
Adv Anat Pathol
January 2025
Department of Pathology, University of Michigan-Michigan Medicine, Ann Arbor, MI.
Uterine smooth muscle neoplasms are a biologically and clinically heterogeneous group of tumors. Morphology is the cornerstone of pathologic diagnosis of these tumors, and most are readily classified as benign or malignant on the basis of routine histologic examination. However, rare subsets-including intravenous leiomyomatosis, benign metastasizing leiomyoma, and disseminated peritoneal leiomyomatosis-have a capacity for extrauterine spread despite benign cytomorphology.
View Article and Find Full Text PDFExtramedullary Hematopoiesis in Serous Cavity Fluids: A Closer Look at This Rare Phenomenon With Diagnostic Pitfalls and Prognostic Significance.
Diagn Cytopathol
December 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Background: Extramedullary hematopoiesis (EMH) is usually seen in the reticuloendothelial system such as the spleen and liver; however, there have been rare case reports when EMH is seen in serous fluids (SFs). The aim of this study included analyzing the cytomorphological features of EMH in SFs in correlation with various clinicopathologic parameters and recognizing potential diagnostic pitfalls as well as their prognostic significance.
Methods: Clinicopathologic parameters and radiologic and pathologic information from the patients with a cytologic diagnosis of EMH were evaluated with cytology slides.
Unveiling Diagnostic Clues of NTRK-Rearranged Spindle Cell Neoplasms in Fine-Needle Aspiration Specimens.
Cytopathology
December 2024
Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
NTRK (neurotropic tropomyosin receptor kinase)-rearranged spindle cell tumours represent a rare group of molecularly defined soft tissue neoplasms. These tumours, excluding infantile fibrosarcomas, are characterised by NTRK gene rearrangements and exhibit a range of histomorphologies, including spindle, epithelioid or rhabdoid cells with invasive growth. Their prognosis correlates with histological grade, and surgical resection is the primary treatment.
View Article and Find Full Text PDFSpitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report with review of the literature.
Diagn Pathol
October 2024
Department of Laboratory Medicine and Pathology, University of Minnesota, Mayo Memorial Building 420 Delaware Street SE, Minneapolis, MN, 55455, USA.
Article Synopsis
- - Spitz tumors are rare melanocytic lesions mostly found in younger individuals but can occur at any age. They usually show distinct cellular features and often have mutations or fusions driving their development.
- - A case study details a 43-year-old woman with a malignant Spitz tumor, identified through histological and immunohistochemical analysis showing various protein expressions. Genetic testing revealed a specific fusion gene (MAP3K8::ABLIM1) and additional mutations linked to a poorer prognosis.
- - This case highlights a new variant of MAP3K8 fusion associated with Spitz melanoma, contributing to our understanding of its diverse cellular and genetic characteristics and potential implications for patient outcomes.
Clinicopathological diagnosis of Lennert lymphoma: a case report and review of the literature.
Diagn Pathol
August 2024
Department of Pathology, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Article Synopsis
- Lennert lymphoma (LL) is a rare type of peripheral T-cell lymphoma that is often misdiagnosed due to unclear diagnostic criteria; careful examination of cytomorphology and immunohistochemistry is crucial for accurate diagnosis.
- A case study highlights a patient diagnosed with LL through these methods, showing small to medium-sized CD4(+) T cells and no indicators of other T cell types, with notable histiocytes and EBV(+) cells present.
- The patient achieved complete remission after chemotherapy and remained disease-free for five years, indicating that accurate diagnosis and treatment can lead to positive outcomes in LL cases.
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