AI Article Synopsis
- Cyclometalated iridium (Ir) complexes are potential agents for biomedical use but face issues due to high cytotoxicity, limiting their effectiveness in imaging and sensing.
- Laponite serves as a promising carrier, providing biocompatibility and stability while effectively adsorbing various functional molecules.
- This approach reduces cytotoxicity, enhances cell uptake, and improves luminescent properties, potentially broadening the use of metal-organic complexes in biomedical applications.
Article Abstract
Cyclometalated Ir complexes are promising candidates for biomedical applications but high cytotoxicity limits their use as imaging and sensing agents. We herein introduce the use of Laponite as carrier for triplet-emitting cyclometalated Ir complexes. Laponite is a versatile nanoplatform because of its biocompatibility, dispersion stability and large surface area that readily adsorbs functional nonpolar and cationic molecules. These inorganic-organic hybrid nanomaterials mask cytotoxicity, show efficient cell uptake and increase luminescent properties and photostability. By camouflaging intrinsic cytotoxicity, this simple method potentially extends the palette of available imaging and sensing dyes to any metal-organic complexes, especially those that are usually cytotoxic.
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| http://dx.doi.org/10.1021/acsami.8b10842 | DOI Listing |
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