The synthesis and photochemical properties of HS-releasing BODIPY thiocarbamate photocage scaffolds activatable by visible-to-NIR (up to 700 nm) light to release carbonyl sulfide (COS), which is transformed to HS using either isolated or natural carbonic anhydrase, is reported. The excellent uncaging cross section and high HS release yields in in vitro experiments, including live-cell imaging, suggest that these photocages can serve as a platform for the bio-orthogonal phototriggered release within the tissue-transparent window.
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| http://dx.doi.org/10.1021/acs.orglett.8b02043 | DOI Listing |
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