AI Article Synopsis
- Developing molecular tools for Rho GTPase signaling helps understand cell function and cytoskeletal changes.
- The EdgeProps computational pipeline enables analysis of cell dynamics and protein activity through fluorescent signaling.
- It features an easy-to-use interface with three modules for processing, visualizing, and statistical analysis of single-cell imaging data.
Article Abstract
Developing molecular tools to visualize and control Rho GTPase signaling in living cells has been instrumental in elucidating the mechanisms of cytoskeletal reorganization and causal relationships between activation events in cell function. An indispensable part of such studies is the quantitative characterization of the spatiotemporal GTPase activity. Here we present a computational pipeline, EdgeProps, designed for comparative/correlative analysis of cell dynamics (edge velocity) and near-edge protein activity (intensity of a fluorescent signal). The tool offers a user-friendly interface with three functional modules for processing, visualization, and statistical characterization of single-cell imaging data.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566099 | PMC |
| http://dx.doi.org/10.1007/978-1-4939-8612-5_4 | DOI Listing |
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