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Diagnostic challenges associated with adrenocortical neoplasms arising from adreno-hepatic fusion: a case report of two patients and a literature review.
Gland Surg
December 2024
Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
Background: A right adrenal gland may present in the form of adreno-hepatic fusion (AHF), in which the adrenal cells are interspersed among the hepatocytes without septation. This rare, naturally-occurring phenomenon may be associated with preoperative misdiagnosis. We present two cases of adrenal tumor in patients with AHF that were misdiagnosed, despite thorough preoperative work-ups.
View Article and Find Full Text PDFPerinatal Management of Hepatic Adenomas.
Obstet Gynecol Surv
December 2024
Assistant Professor, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN.
Importance: With a strong association between hepatic adenomas and estrogen established, understanding the risks, evaluation, and perinatal management of hepatic adenomas is necessary for obstetric clinicians.
Objective: The aim of this study is to review the preconception counseling, perinatal management, and postpartum care of hepatic adenomas.
Evidence Acquisition: A literature review identified relevant research, review articles, textbook chapters, databases, and societal guidelines.
Glycogen Storage Disease Type Ia: A Retrospective Claims Analysis of Complications, Resource Utilization, and Cost of Care.
J Health Econ Outcomes Res
January 2025
Ultragenyx Pharmaceutical Inc., Novato, CA, USA.
Glycogen storage disease type Ia (GSDIa) is a rare inherited disorder resulting in potentially life-threatening hypoglycemia, metabolic abnormalities, and complications often requiring hospitalization. This retrospective database analysis assessed the complications, resource utilization, and costs in a large cohort of patients with GSDIa. We conducted a retrospective cohort study of GSDIa patients and matched non-GSDIa comparators utilizing the PharMetrics® Plus database.
View Article and Find Full Text PDFA comprehensive study on the feasibility and diagnostic potential of fluctuation imaging in liver tumor assessment.
Sci Rep
December 2024
Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 03080, Korea.
Ultrasound (US) is a widely used technique for liver disease but has limitations in distinguishing tumors. This study evaluates the clinical efficacy of fluctuational imaging (FLI), a new US method that detects the fluttering sign in liver tumors. We conducted a prospective exploratory study with 120 participants diagnosed with liver tumors through histopathology or standard imaging.
View Article and Find Full Text PDFImmunohistochemical basis for FAP as a candidate theranostic target across a broad range of cholangiocarcinoma subtypes.
Front Nucl Med
November 2024
Department of Radiology, Mayo Clinic, Rochester, MN, United States.
Article Synopsis
- This study investigates the expression and location of fibroblast activation protein (FAP) in various liver tumors, focusing on cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), hepatocellular adenoma (HCA), and focal nodular hyperplasia (FNH).
- FAP immunostaining results showed that a high percentage of CCA exhibited moderate to strong FAP expression compared to other tumor types, indicating a significant distinction.
- The findings suggest that FAP is consistently present in CCA tumor stroma regardless of clinical features, highlighting its potential as a target for future diagnostic and therapeutic strategies in treating different CCA subtypes.
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