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| http://dx.doi.org/10.1136/bcr-2018-226516 | DOI Listing |
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Update on Conventional Osteosarcoma.
Rev Bras Ortop (Sao Paulo)
December 2024
Grupo de Oncologia Pediátrico, Hospital das Clínicas, Belo Horizonte, MG, Brasil.
Conventional osteosarcoma is a high-grade malignant tumor characterized by the production of osteoid matrix by malignant osteoblasts. It typically affects the long bones of children and adolescents. Treatment includes systemic chemotherapy and a local surgical approach with wide resection.
View Article and Find Full Text PDFRare presentation of Ewing's sarcoma underscores the diagnostic challenges in atypical cases.
BMJ Case Rep
December 2024
Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Article Synopsis
- A young female patient experienced worsening right-sided chest pain and high-grade fever over 15 days, prompting a medical evaluation.
- Physical exams showed tenderness and reduced air entry in her right lung, leading to imaging that revealed a pleural effusion and a chest wall mass.
- After testing, instead of tuberculosis, the mass was diagnosed as Ewing's sarcoma, atypical for its usual presentation, highlighting the complexities of diagnosing rare conditions in TB-endemic areas.
Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion.
Genes Chromosomes Cancer
November 2024
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Conventional high-grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of osteosarcomas remain challenging due to unusual histology, such as sclerosing or osteoblastoma-like features, which may require molecular confirmation of their complex genetic alterations. We have encountered such a case in a 17-year-old man, who presented with a third metatarsal sclerotic bone lesion, found incidentally in the work-up of a foot trauma.
View Article and Find Full Text PDFThe Interplay Between the Oncogene and Ribosomal Proteins in Osteosarcoma Onset and Progression: Potential Mechanisms and Indication of Candidate Therapeutic Targets.
Int J Mol Sci
November 2024
Center for Applied Biomedical Research (CRBA), Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
High-grade osteosarcoma (OS) is the most common primary bone tumor mainly affecting children and young adults. First-line treatment consists of neo-adjuvant chemotherapy with doxorubicin, cisplatin, and methotrexate and surgery. The mean long-term survival rate for localized disease at diagnosis is 65-70%, dropping down to 20% when metastases are present at diagnosis.
View Article and Find Full Text PDFPrognostic Significance of Microvessel Density and Hypoxic Markers in Canine Osteosarcoma: Insights into Angiogenesis and Tumor Aggressiveness.
Animals (Basel)
November 2024
Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.
Canine osteosarcoma (OSA) is an aggressive and highly malignant tumor of bone with a poor prognosis and it mirrors the disease in humans. Angiogenesis, the formation of new blood vessels, is driven by hypoxia-induced factors such as HIF-1α and VEGF, both of which play a crucial role in tumor growth and metastasis. However, the role of angiogenesis in OSA remains a topic of ongoing debate.
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