AI Article Synopsis
- Long noncoding RNAs (lncRNAs) are emerging as significant players in cancer biology, with potential roles as biomarkers and therapeutic targets.
- The study focused on LINC00641, a lncRNA that was found to be down-regulated in bladder cancer tissues, which correlates with poor patient prognosis.
- Experimentation showed that increasing LINC00641 levels inhibited bladder cancer cell growth and invasion while also revealing a mechanism where LINC00641 interacts with miR-197-3p and up-regulates KLF10, leading to suppression of the PTEN/PI3K/AKT signaling pathway, ultimately hindering bladder cancer progression.
Article Abstract
As a new group of important effector molecules involved in multiple cancers, long noncoding RNAs (lncRNAs) have attracted much attention recently. Especially, evidences have indicated lncRNAs might be promising biomarkers and targets for cancer therapy. LINC00641 is a novel lncRNA, whose function remains totally unclear. The aim of our study was to determine the functions of LINC00641 in bladder cancer. We found that LINC00641 expression was significantly down-regulated in bladder cancer tissues. Down-regulation of LINC00641 in patients with bladder cancer predicts poor prognosis. Gain-of-function assays indicated that LINC00641 up-regulation markedly inhibited the proliferation, migration and invasion of bladder cancer cells. Xenograft assay also confirmed that LINC00641 overexpression suppressed bladder cancer growth in vivo. Mechanistically, LINC00641 was demonstrated to interact with miR-197-3p, whose target was KLF10. By up-regulating KLF10 level, LINC00641 suppressed the PTEN/PI3K/AKT pathway, leading to prevention of bladder cancer progression. Taken together, our study illustrated a novel signaling cascade of LINC00641/miR-197-3p/KLF10/PTEN/PI3K/AKT pathway regulating bladder cancer development.
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| http://dx.doi.org/10.1016/j.bbrc.2018.07.120 | DOI Listing |
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