Aim: A study was carried out to determine if the presence of microtropia with identity is a reliable indicator for the presence of amblyopia, and likely need for occlusion, following optical treatment in "straight-eyed" anisometropic children.
Method: A retrospective case note review was carried out of all children referred from Orthoptic school vision screening during a 10-year period. Children who had unequal visual acuity, no manifest strabismus and who were prescribed spectacles to correct anisometropia (inter-ocular difference one dioptre or more in any meridian) were included in the study. The presence or absence of microtropia with identity, determined using the 4-dioptre prism test, was recorded and children were grouped according to visual outcome as follows: Group 1: equal visual acuity after a maximum optical treatment period of 2 months; Group 2: equal visual acuity after a maximum optical treatment period of 6 months; Group 3: unequal visual acuity after a maximum optical treatment period of 6 months - no occlusion therapy undertaken; and Group 4: unequal visual acuity after a maximum optical treatment period of 6 months - occlusion therapy undertaken.
Results: Case notes were available for a total of 532 children. Out of 532, 324 children achieved equal visual acuity with optical treatment alone; none had microtropia. Thirty children with microtropia achieved LogMAR acuity of 0.200 or better in the affected eye after optical treatment and did not undergo occlusion therapy; 178 children required occlusion therapy to achieve a maximum LogMAR acuity of 0.300 or better, and all had microtropia.
Conclusion: In this study of 532 four-five year olds, amblyopia did not exist in "straight-eyed" anisometropic children who did not have microtropia with identity. This study suggests that the presence of microtropia with identity is a reliable indicator of the presence of amblyopia, and possible need for occlusion therapy, following optical treatment in "straight-eyed" anisometropic children.
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http://dx.doi.org/10.1080/09273972.2018.1503308 | DOI Listing |
Adv Sci (Weinh)
January 2025
College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials in corneal wound healing, currently available nanozymes lack sufficient catalytic activity and the ability to penetrate bacterial biofilms, limiting their efficacy against the treatment of BK. To remedy this, ZnFe layered double hydroxide (ZnFe-LDH) nanosheets are loaded with Cu single-atom nanozymes (Cu-SAzymes) and aminated dextran (Dex-NH), resulting in the formation of the nanozyme DT-ZnFe-LDH@Cu, which possesses peroxidase (POD)-, oxidase (OXD)-, and catalase (CAT)-like catalytic activities.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Precise and effective management of myocardial ischemia/reperfusion injury (MIRI) is still a formidable challenge in clinical practice. Additionally, real-time monitoring of drug aggregation in the MIRI region remains an open question. Herein, a drug delivery system, hesperadin and ICG assembled in PLGA-Se-Se-PEG-IMTP (HI@PSeP-IMTP), is designed to deliver hesperadin and ICG to the MIRI region for in vivo optical imaging tracking and to ameliorate MIRI.
View Article and Find Full Text PDFFront Pediatr
January 2025
Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People's Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, China.
Introduction: Increased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. The optic nerve sheath diameter (ONSD) is a new indicator for the assessment of intracranial pressure using ultrasound, CT scan and MRI imaging. Given the influence of physical development on ONSD size in children, we expect more accurate assessment of intracranial pressure with ONSD/ETD (eyeball transverse diameter) ratio by ultrasound.
View Article and Find Full Text PDFFacioscapulohumeral muscular dystrophy type 1 (FSHD1) and Becker muscular dystrophy (BMD) are distinct disorders caused by different genetic variations and exhibiting different inheritance patterns. The co-occurrence of both conditions within the same family is rare. In this case report, the proband was a 10 year-old boy who presented with eye and mouth orbicular muscles, shoulder and proximal upper and lower limbs weakness.
View Article and Find Full Text PDFCureus
December 2024
Department of Ophthalmology, The University of Jordan, Amman, JOR.
We present the case of a 23-year-old male who experienced vision loss in his left eye 15 months after undergoing bilateral transepithelial photorefractive keratectomy (T-PRK). Despite the absence of any significant preoperative topographical risk factors in either eye, corneal ectasia was later confirmed in the left eye, while the right eye remained normal. Subtle asymmetry in topometric indices and a borderline high Index of vertical asymmetry (IVA) reading suggested the possibility of early subclinical keratoconus, potentially increasing the risk of post-refractive ectasia.
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