AI Article Synopsis
- The study involves a chemical reaction that creates isoxazolidine compounds by combining a specific nitrone with 6-bromo-2-vinyl-3-quinazolin-4-ones.
- These newly formed isoxazolidines were tested for their ability to inhibit various DNA and RNA viruses, showing effectiveness against strains of varicella-zoster virus and human cytomegalovirus.
- Some isoxazolidines also displayed moderate ability to inhibit the growth of human lymphocyte cells at certain concentrations.
Article Abstract
1,3-Dipolar cycloaddition of -methyl -(diethoxyphosphoryl) nitrone to N3-substituted 6-bromo-2-vinyl-3-quinazolin-4-ones gave (3-diethoxyphosphoryl) isoxazolidines substituted at C5 with quinazolinones modified at N3. All isoxazolidine cycloadducts were screened for antiviral activity against a broad spectrum of DNA and RNA viruses. Several isoxazolidines inhibited the replication of both thymidine kinase wild-type and deficient (TK⁺ and TK) varicella-zoster virus strains at EC in the 5.4⁻13.6 μΜ range, as well as human cytomegalovirus (EC = 8.9⁻12.5 μΜ). Isoxazolidines -, -, -, -/-, -, -, and -/- exhibited moderate cytostatic activity towards the human lymphocyte cell line CEM (IC = 9.6⁻17 μM).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222691 | PMC |
| http://dx.doi.org/10.3390/molecules23081889 | DOI Listing |
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