AI Article Synopsis
- * Changes in the composition of respiratory and gut microbiota are being studied to understand how they contribute to disease development and progression.
- * The review highlights recent research on how host defense peptides and proteins influence microbiota composition and discusses potential therapeutic strategies to restore balance in cases of microbiota dysbiosis related to chronic lung diseases.
Article Abstract
The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of novel therapeutic strategies aimed at restoring host-microbiota homeostasis. In this review, we discuss recent literature on host-microbiota interactions in the respiratory tract, with a specific focus on the influence of endogenous host defence peptides and proteins (HDPs) on the composition of microbiota populations in vivo and explore possible HDPs-related therapeutic approaches targeting microbiota dysbiosis in chronic inflammatory lung diseases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161034 | PMC |
| http://dx.doi.org/10.3390/vaccines6030049 | DOI Listing |
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