AI Article Synopsis
- The study investigated amplification units in tumors with myc gene amplifications, focusing on their genomic structures.
- In neuroblastomas with N-myc amplifications, the amplification units were consistently around 290 to 430 kilobases and showed high conservation across different tumors.
- In contrast, c-myc amplifications in five tumor cell lines displayed more variability in amplification unit sizes (90 to 300 kilobases) and sequencing patterns, with at least three distinct amplification patterns identified.
Article Abstract
The amplification units in human tumors containing amplified myc genes were examined. The amplification unit in all cases consisted of a large genomic region coamplified with the coding region of the myc genes themselves. In eight independent neuroblastomas containing N-myc amplifications, the amplification unit was estimated to be 290 to 430 kilobases. This amplification unit was highly conserved among the different neuroblastomas, with some neuroblastomas containing almost identical units. In contrast, five tumor cell lines containing c-myc amplifications exhibited amplification units that were more variable in size (90 to 300 kilobases) and sequence content; at least three different patterns of c-myc amplification units could be discerned.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC323004 | PMC |
| http://dx.doi.org/10.1073/pnas.83.4.1031 | DOI Listing |
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