AI Article Synopsis
- The study aimed to identify the plasma metabolic profile linked to childhood obesity and its different metabolic types.
- Plasma samples from 65 obese and 37 normal-weight children were analyzed using proton NMR spectroscopy, revealing variations in metabolite concentrations.
- Results indicated that obese children had elevated lipids and lactate but lower amino acids and glucose levels compared to normal-weight peers; findings suggest potential for using proton NMR metabolomics in diagnosing and understanding childhood obesity.
Article Abstract
Aim: To identify the plasma metabolic profile associated with childhood obesity and its metabolic phenotypes.
Materials & Methods: The plasma metabolic profile of 65 obese and 37 normal-weight children was obtained using proton NMR spectroscopy. NMR spectra were rationally divided into 110 integration regions, which reflect relative metabolite concentrations, and were used as statistical variables.
Results: Obese children show increased levels of lipids, N-acetyl glycoproteins, and lactate, and decreased levels of several amino acids, α-ketoglutarate, glucose, citrate, and cholinated phospholipids as compared with normal-weight children. Metabolically healthy children show lower levels of lipids and lactate, and higher levels of several amino acids and cholinated phospholipids, as compared with unhealthy children.
Conclusion: This study reveals new valuable findings in the field of metabolomics and childhood obesity. Although validation should be performed, the proof of principle looks promising and justifies a deeper investigation of the diagnostic possibilities of proton NMR metabolomics in follow-up studies. NCT03014856. Registered January 9, 2017.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060399 | PMC |
| http://dx.doi.org/10.4155/fsoa-2017-0146 | DOI Listing |
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