Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against spp. and .
Methods: The ability of CHT to act in biofilm and also to interfere with adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models.
Results & Conclusion: In the present work we verified that CHT is found to inhibit and affecting biofilm in both and inhibited adhesion of to human buccal cells. When we evaluated , CHT prolonged survival of after infections with , or and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060395 | PMC |
| http://dx.doi.org/10.4155/fsoa-2018-0001 | DOI Listing |
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