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Background: In this study, 18 methanol extracts from Cameroonian edible plants were tested for their antibacterial activities against 26 strains of ; the role of efflux pumps in the resistance of tested bacteria and the antibiotic resistance-modulating activities against selected multidrug-resistant (MDR) phenotypes were also investigated.
Methods: Broth microdilution assay was used to evaluate the antibacterial activity, the role of efflux pumps, and the antibiotic resistance-modulating effects of plant extracts.
Results: Extracts from seeds (DES) and bark (DEB) were active against all 26 tested bacterial strains, within the minimal inhibitory concentration (MIC) range of 256-1024 g/mL. MIC values varied from 64 to 1024 g/mL against 96.2% of the 26 tested bacteria for leaves (PVL), 92.3% for bark (AIB), leaves (DEL), and leaves (RHL). The lowest MIC value of 64 g/mL was obtained with the extract from beans (CMB) against MRSA4 strain and from bark (UGB) against MRSA9 strain. Bacterial efflux pump inhibitor (EPI), carbonyl cyanide -chlorophenyl hydrazone (CCCP), improved the activity of DES and UGB as well as that of extracts from leaves (HEL) and leaves (UGL) against resistant strains. Antibiotic-modulating effects against more than 70% of the strains tested were obtained when RHL (at MIC/2) was combined with CIP, ERY, and KAN (88.89%), CHL (88.89%), TET (77.78%), and STR (88.89%).
Conclusion: The present study demonstrated that the 13 tested plants had antistaphylococcal effects and that DES, HEL, UGL, and UGB could be used in combination with EPI to combat resistance to . Also, it demonstrated that some studied extracts and mostly RHL could be used as antibiotic resistance modulators to fight against resistant strains of .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051259 | PMC |
| http://dx.doi.org/10.1155/2018/1920198 | DOI Listing |
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