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Current and Emerging Techniques for Diagnosis of Toxoplasmosis in Pregnancy: A Narrative Review.
Iran J Parasitol
January 2024
Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran.
is an intracellular parasite capable of crossing the placenta in pregnancy and infecting the developing fetus, leading to various congenital anomalies and even abortion. Acute infection is responsible for almost all cases of congenital toxoplasmosis in immunocompetent pregnant women. Prenatal screening for acute toxoplasmosis primarily involves maternal serology and fetal ultrasound imaging.
View Article and Find Full Text PDFHuman Cytomegalovirus Replication Enhanced By Placental MicroRNAs.
J Med Virol
December 2024
Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Placental trophoblasts constitute the interface between the fetal and maternal environments and physically prevent maternal-fetal viral transmission. However, congenital human cytomegalovirus (HCMV) infection in the early stages of pregnancy results in severe symptoms in the fetus. HCMV is the most common causative agent of intrauterine infection.
View Article and Find Full Text PDFThe mechanism of all-trans retinoic acid-induced cleft palate may be related to the novel ENSMUST00000159153-miR-137-5p-Wnt7a and ENSMUST000000236086-miR-34b-3p-EphA10/TRPM2 ceRNA crosstalk.
Environ Toxicol Pharmacol
December 2024
Center for Clinical Single-Cell Biomedicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou450003, Henan, China. Electronic address:
Cleft palate is the most prevalent congenital condition. Cleft palate is brought on by an exogenous chemical called all-trans retinoic acid (atRA). In order to indirectly control gene expression, long chain non-coding RNAs (lncRNAs) act as competitive endogenous RNA (ceRNA) sponges.
View Article and Find Full Text PDFEvaluation of mesenchymal stem cells as an model for inherited retinal diseases.
Front Cell Dev Biol
November 2024
Sirius University of Science and Technology, Krasnodar, Russia.
Article Synopsis
- Retinal pathologies, particularly inherited retinal diseases (IRDs) like retinitis pigmentosa, are key contributors to vision impairment and blindness, necessitating effective research models for understanding and developing treatments.
- Various types of cells, including retina-specific cell lines, primary retinal cells, and mesenchymal stem cells (MSCs), can be utilized to create models of IRDs, with a focus on MSCs due to their effective differentiation into retinal cells.
- MSC-based models offer advantages over induced pluripotent stem cell (iPSC) models, being cheaper and quicker for drug screening purposes; however, the methods for differentiation still require optimization for better results.
Elevated microRNA-187 causes cardiac endothelial dysplasia to promote congenital heart disease through inhibition of NIPBL.
J Clin Invest
November 2024
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Article Synopsis
- Cardiac endothelial cells are crucial for heart development, and disruptions can lead to congenital heart disease (CHD); this study discovered that elevated levels of miR-187 in these cells from CHD fetuses directly contribute to the condition.
- The research demonstrated that increased miR-187 inhibits NIPBL, a protein necessary for proper gene expression and chromatin accessibility, resulting in impaired endothelial cell development and heart defects in mouse models.
- By mimicking these defects in human cardiac organoids and showing that restoring NIPBL can reverse issues, the findings highlight the miR-187/NIPBL pathway as a potential target for new CHD therapies.
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