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Rome Foundation Working Team Report: Consensus Statement on the Design and Conduct of Behavioural Clinical Trials for Disorders of Gut-Brain Interaction.
Aliment Pharmacol Ther
January 2025
Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Background: Brain-gut behaviour therapies (BGBT) have gained widespread acceptance as therapeutic modalities for the management of disorders of gut-brain interaction (DGBI). However, existing treatment evaluation methods in the medical field fail to capture the specific elements of scientific rigour unique to behavioural trial evaluation.
Aims: To offer the first consensus on the development and testing of BGBT in DGBI.
Progress in 3D Printing Applications for the Management of Orbital Disorders: A Systematic Review.
Bioengineering (Basel)
December 2024
Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
: 3D printing technology has gained considerable interest in the domain of orbital illnesses owing to its capacity to transform diagnosis, surgery planning, and treatment. This systematic review seeks to deliver a thorough examination of the contemporary applications of 3D printing in the treatment of ocular problems, encompassing tumors, injuries, and congenital defects. This systematic review of recent studies has examined the application of patient-specific 3D-printed models for preoperative planning, personalized implants, and prosthetics.
View Article and Find Full Text PDFIntegrated Design and Prototyping of a Robotic Head for Ocular and Craniofacial Trauma Simulators.
Int J Med Robot
February 2025
Department of Mechanical, Energy, Management and Transportation Engineering, University of Genova, Genova, Italy.
Background: Medical simulation is relevant for training medical personnel in the delivery of medical and trauma care, with benefits including quantitative evaluation and increased patient safety through reduced need to train on patients.
Methods: This paper presents a prototype medical simulator focusing on ocular and craniofacial trauma (OCF), for training in management of facial and upper airway injuries. It consists of a physical, electromechanical representation of head and neck structures, including the mandible, maxillary region, neck, orbit and peri-orbital regions to replicate different craniofacial traumas.
Real-world effectiveness and safety of ibrutinib in patients with chronic lymphocytic leukemia in Japan: the Orbit study.
Int J Hematol
November 2024
Department of Medical Technology, Faculty of Medical Technology, Niigata University of Pharmacy and Medical and Life Sciences, Niigata, Japan.
Article Synopsis
- * The Orbit study aimed to evaluate real-world outcomes for adults with CLL/SLL in Japan treated with ibrutinib between July 2018 and December 2020, including 246 patients in total.
- * After 36 months, the study showed an 80.9% progression-free survival rate for first-line treatment and 67.2% for relapsed cases, with common significant side effects including bleeding and infections, underscoring ibr
Orbital computed tomography imaging characteristics of thyroid-associated ophthalmopathy.
Sci Rep
November 2024
The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, No. 463 Bayi Avenue, Nanchang City, 330006, Jiangxi Province, China.
This study aims to investigate the distribution characteristics and correlations of orbital soft tissue volume expansion in patients with thyroid-associated ophthalmopathy (TAO) by analyzing orbital computed tomography (CT) data and to determine the most appropriate parameters and corresponding cut-off values for imaging classification. Patients with TAO who met the inclusion and exclusion criteria, along with those with lacrimal duct obstruction requiring orbital CT examination, were included in the study. Raw CT data were imported into Mimics and RadiAnt software for analysis, and measurements of orbital volume, orbital fat volume, extraocular muscle volume, optic nerve volume, and exophthalmos were obtained.
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