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Endothelial Function of Patients with Morbid Obesity Submitted to Roux-en-Y Gastric Bypass With and Without Obstructive Sleep Apnea-Hypopnea Syndrome. | LitMetric

Endothelial Function of Patients with Morbid Obesity Submitted to Roux-en-Y Gastric Bypass With and Without Obstructive Sleep Apnea-Hypopnea Syndrome.

Obes Surg

Programa de Pós-graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.

Published: November 2018

AI Article Synopsis

  • Obesity is linked to obstructive sleep apnea-hypopnea syndrome (OSA), both of which cause endothelial dysfunction, and this study investigates how OSA affects endothelial function post-bariatric surgery.
  • The research was conducted in Brazil with 56 patients divided into two groups (with and without OSA), who underwent Roux-en-Y gastric bypass and were assessed before and 6 months after surgery.
  • Findings showed that while bariatric surgery improved overall health and OSA symptoms, patients with OSA experienced a lesser improvement in endothelial function compared to those without OSA.

Article Abstract

Background: Obesity is associated with obstructive sleep apnea-hypopnea syndrome (OSA) and both induce endothelial dysfunction. However, the effect of OSA on endothelial function after bariatric surgery has not been investigated yet.

Objectives: This study aims to evaluate the impact of weight loss on endothelial function in patients with and without obstructive sleep apnea (OSA) in the first 6 months after bariatric surgery.

Setting: This study was conducted at a university hospital, in Brazil.

Methods: The sample consisted of 56 patients homogeneously divided into groups with and without OSA. All patients underwent Roux-en-Y gastric bypass (RYGB), and the diagnosis of OSA was performed by polysomnography. The patients were evaluated preoperatively and 6 months after surgery. The evaluations included anthropometric measures, electrical bioimpedance, clinical symptoms of OSA, and endothelial function (flow-mediated dilation). RYGB improved the anthropometric, bioimpedance, and endothelial function results in both groups.

Results: Patients presented a significant clinical improvement in OSA symptoms throughout the study. However, patients with OSA had an improvement in the endothelial function 2.5% lower (p < 0.001) than patients without APNEA syndrome.

Conclusion: This study demonstrates that the existence of OSA prior to bariatric surgery interferes in the improvement of endothelial function.

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Source
http://dx.doi.org/10.1007/s11695-018-3403-9DOI Listing

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