AI Article Synopsis
- Biofilms are a common growth form for microorganisms, offering survival advantages but creating challenges in medical and industrial contexts due to their resistance to antimicrobials.
- Exposure to subinhibitory levels of antimicrobials can enhance biofilm production and lead to treatment failures as it promotes the survival of resistant bacteria.
- The review explores mechanisms of biofilm stimulation from subinhibitory antimicrobials and potential strategies to utilize this understanding in treating biofilm-associated infections and discovering new treatments.
Article Abstract
Biofilms are a typical mode of growth for most microorganisms and provide them with a variety of survival benefits. Biofilms can pose medical and industrial challenges due to their increased tolerance of antimicrobials and disinfectants. Exposure of bacteria to subinhibitory concentrations of those compounds can further exacerbate the problem, as they provoke physiological changes that lead to increased biofilm production and potential therapeutic failure. The protected niche of a biofilm provides conditions that promote selection for persisters and resistant mutants. In this review we discuss our current understanding of the mechanisms underlying biofilm stimulation in response to subinhibitory antimicrobials, and how we might exploit this 'anti-antibiotic' phenotype to treat biofilm-related infections and discover new compounds.
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| http://dx.doi.org/10.1016/j.mib.2018.07.006 | DOI Listing |
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