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Polyacrylamide Hydrogels Produce Hydrogen Peroxide from Osmotic Swelling in Aqueous Media. | LitMetric

AI Article Synopsis

  • This study shows that weak polyacrylamide hydrogels produce hydrogen peroxide (HO) due to mechanical stresses from osmotic swelling.
  • The amount of HO generated varies based on the type of crosslinkers used, with weaker crosslinkers leading to higher HO levels compared to stronger ones.
  • The findings highlight that even stable hydrogels can undergo unexpected chemical changes over time, which is important for researchers in the 3D cell culture field.

Article Abstract

This work demonstrates that hydrogen peroxide (HO) is generated in weak polyacrylamide hydrogels due to mechanochemical reactions to osmotic swelling. Hydrogels are important tools and materials for many biomedical applications, particularly for growth of stem cells. However, swollen gels are under constant tension, which makes their individual chains susceptible to mechanochemical bond breakage. In this work, an assay was developed to measure the generation of HO as a result of hydrogel swelling. Polyacrylamide hydrogels with both weak disulfide and strong PEG-diacrylate crosslinkers were synthesized and swelled. HO generation increased in the presence of weaker crosslinkers, up to 30 μM HO, whereas stronger crosslinkers reduced this to 5 μM HO. HO levels decreased when swelled in the presence of dextran to reduce osmotic stress or increased if the gels were conjugated to an acrylated surface. Finally, HO continued to form for days after the gels had reached their equilibrium sizes, independently of dissolved oxygen. The results of this work impact those working in the 3D cell culture community and demonstrate that even well-characterized systems undergo mechanochemical processes in mild environments.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687575PMC
http://dx.doi.org/10.1021/acs.biomac.8b00743DOI Listing

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