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Right ventricular remodeling in complex congenital heart disease.
Can J Cardiol
January 2025
Research Center, Montreal Heart Institute, Department of Medicine, Université de Montréal, Montreal, Canada; Adult Congenital Heart Centre, Montreal Heart Institute, Université de Montréal, Montreal, Canada. Electronic address:
In congenital heart diseases (CHD) of moderate to great complexity involving the right ventricle (RV), the morphologic RV can be exposed to significant stressors across the lifespan either in a biventricular circulation in a sub-pulmonary or sub-aortic position, or as part of a univentricular circulation. These include pressure and/or volume overload, hypoxia, ischemia, and periprocedural surgical stress leading to remodeling, maladaptation, dilation hypertrophy and dysfunction. This review examines the macroscopic remodeling of the RV in various forms of CHD and explores remodeling trajectories, along with the effects of surgeries and residual lesion repair, in tetralogy of Fallot, Ebstein anomaly, congenitally corrected transposition of the great arteries, transposition of the great arteries with atrial switch surgery, and single ventricle palliated by Fontan.
View Article and Find Full Text PDFThree-dimensional speckle-tracking echocardiography-derived deformation analysis of the morphologic left ventricle in adults with corrected dextro-transposition of the great arteries-insights from the CSONGRAD Registry and MAGYAR-Path Study.
Cardiovasc Diagn Ther
December 2024
Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Background: Dextro-transposition of the great arteries (dTGA) stands out as a prevalent cyanotic congenital heart defect (CHD), characterized by an intricate reversal in the arrangement of the major arteries. In the past, several surgical procedures have been used to treat dTGA, including the atrial switch. Although the method is no longer used, survivors of the procedure still living among us.
View Article and Find Full Text PDFReverse Mutations in Pigmentation Induced by Sodium Azide in the IR64 Rice Variety.
Curr Issues Mol Biol
November 2024
Department of Agronomy, National Chung Hsing University, Taichung 402, Taiwan.
Pigmentation in rice is due mainly to the accumulation of anthocyanins. Five color mutant lines, AZ1701, AZ1702, AZ1711, AZ1714, and AZ1715, derived from the sodium azide mutagenesis on the non-pigmented IR64 variety, were applied to study inheritance modes and genes for pigmentation. The mutant line AZ1711, when crossed with IR64, displays pigmentation in various tissues, exhibiting a 3:1 pigmented to non-pigmented ratio in the F progeny, indicating a single dominant locus controlling pigmentation.
View Article and Find Full Text PDFMigratory Aryl Cross-Coupling.
J Am Chem Soc
January 2025
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, Massachusetts 02138, United States.
Article Synopsis
- Cross-coupling reactions are defined by regiospecificity, meaning the bond formation site is influenced by the position of the leaving group.
- Researchers propose a new method to create multiple structural isomers from the same coupling partners instead of synthesizing new isomer starting materials.
- The study demonstrates the use of a bulky palladium catalyst to enable efficient transposition of aryl halides, allowing high yields of unconventional product isomers through dynamic kinetic resolution combined with various nucleophiles.
Chronic Exposure of Zebrafish to Iron and Aluminum: Evaluation of Reversal and Generational Transposition of Behavioral, Histopathological, and Genotoxic Changes.
Environ Toxicol
November 2024
Post Graduation Program in Environmental Quality, Feevale University, Novo Hamburgo, Rio Grande do Sul, Brazil.
Article Synopsis
- This study examined the chronic effects of various concentrations of iron (Fe) and aluminum (Al) on zebrafish, looking at potential changes in behavior, health, and genetics.
- Significant locomotion changes and histopathological alterations, especially related to aluminum exposure, were noted even after recovery periods, indicating lasting impacts on the fish.
- The findings stress the need for updated environmental guidelines and monitoring, as low levels of pollutants can still cause harm to aquatic life and affect future generations.
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