We have developed a general method for reverse aromatic Finkelstein reactions. Good reaction yields were obtained when aryl iodides or aryl bromides were treated with copper halide salts as promoters in a 1-butyl-3-methylimidazolium bromide ([BMIM]Br) ionic liquid (IL) solvent at 140 °C for 8 h. Preliminary investigation supported that the copper salts were also the halide sources in halogen exchange reactions. The optimized conditions are applicable to a variety of substrates and have excellent functional group tolerance. Additionally, the [BMIM]Br solvent showed good stability for at least 10 consecutive runs. Results indicated that the [BMIM]Br solvent was recyclable for reverse aromatic Finkelstein reactions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057234 | PMC |
| http://dx.doi.org/10.1016/j.jare.2017.12.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification, characterization, and expression of Oryza sativa tryptophan decarboxylase genes associated with fluroxypyr-meptyl metabolism.
Plant Genome
March 2025
Guangxi Key Laboratory of Agric-Environment and Agric-Products Safety, College of Agriculture, Guangxi University, Nanning, China.
Tryptophan decarboxylase (TDC) belongs to a family of aromatic amino acid decarboxylases and catalyzes the conversion of tryptophan to tryptamine. It is the enzyme involved in the first step of melatonin (MT) biosynthesis and mediates several key functions in abiotic stress tolerance. In Oryza sativa under pesticide-induced stress, TDC function is unclear.
View Article and Find Full Text PDFGenome-wide association analysis of key genes for feed efficiency in Qingyuan Partridge chickens.
Poult Sci
December 2024
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan 528225, China; Guangdong Tinoo's Food Co., Ltd., Qingyuan, Guangdong 511500, China. Electronic address:
Qingyuan Partridge chickens represent a notable breed of high-quality, slow-growing chickens. The cost of feed constitutes 65-70 % of the total breeding expense for Qingyuan Partridge chickens. Enhancing feed utilization efficiency and reducing feed consumption are crucial for the advancement of Qingyuan Partridge chickens and the broader poultry industry.
View Article and Find Full Text PDFCharacterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines.
Nat Commun
January 2025
Key Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P R China.
Prenylation modifications of natural products play essential roles in chemical diversity and bioactivities, but imidazole modification prenyltransferases are not well investigated. Here, we discover a dimethylallyl tryptophan synthase family prenyltransferase, AuraA, that catalyzes the rare dimethylallylation on the imidazole moiety in the biosynthesis of aurantiamine. Biochemical assays validate that AuraA could accept both cyclo-(L-Val-L-His) and cyclo-(L-Val-DH-His) as substrates, while the prenylation modes are completely different, yielding C2-regular and C5-reverse products, respectively.
View Article and Find Full Text PDFReversed Allylation of 3-Alkenyl Indoles Using Allyl Boronic Acids: Access to Tryptamine Based Alkaloids.
Chemistry
January 2025
Indian Institute of Technology Kharagpur, Chemistry, Paschim Midnapore, 721302, Kharagpur, INDIA.
All-carbon quaternary and tertiary stereocenters connected at the C2-position of functionalizable C3-alkylated indole nucleus are commonly occurring frameworks found in many indole alkaloids of medicinal importance. Their direct access is scarcely reported, a long-standing problem, and developing a unique yet simple method can pave the pathway to an entirely different retrosynthetic route for the total synthesis of these alkaloids. Herein, this problem is addressed by developing an unprecedented branch-selective allylation strategy employing a broad range of structurally and electronically different 3-alkenyl-indoles and allylboronic acids.
View Article and Find Full Text PDFDesign and Regulation of Anthraquinone's Electrochemical Properties in Aqueous Zinc-Ion Batteries via Benzothiadiazole and Its Dinitro Derivatives.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, and Department of Macromolecular Science and Engineering, School of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China.
Article Synopsis
- Organic cathode materials are promising for aqueous zinc-ion batteries (AZIBs) due to their low cost and tunable properties, with benzothiadiazoles showing potential for effective electron acceptance.
- A new polymer, PBDQ-N, was designed by adding nitro groups to enhance electron delocalization and increase active sites, resulting in better zinc-ion insertion/extraction.
- PBDQ-N exhibited exceptional electrochemical performance with a specific capacity of 446.2 mAh/g and a cycle life of over 20,000 cycles, highlighting the importance of molecular design in optimizing battery materials.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!