AI Article Synopsis
- This study explores the use of In-exendin, a radiotracer, for measuring changes in β-cell mass during the progression of type 1 diabetes in a rat model.
- BBDP rats were injected with In-exendin, and SPECT imaging showed a strong correlation between radiotracer accumulation and β-cell mass percentage.
- The findings suggest that In-exendin could effectively track β-cell mass changes in diabetes development, regardless of the presence of insulitis.
Article Abstract
The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of In-diethylenetriaminepentaacetic acid-exendin-3 (In-exendin) in a rat model that closely mimics the development of type 1 diabetes (T1D) in humans: BioBreeding diabetes-prone (BBDP) rats. BBDP rats of 4-18 weeks of age were injected intravenously with In-exendin, and single-photon emission computed tomography (SPECT) images were acquired. The accumulation of the radiotracer was measured as well as the BCM and grade of insulitis by histology. In-exendin accumulated specifically in the islets, resulting in a linear correlation with the BCM (%) (Pearson = 0.89, < 0.0001, and = 0.64 for SPECT). Insulitis did not have an influence on this correlation. These results indicate that In-exendin is a promising tracer to determine the BCM during the development of T1D, irrespective of the degree of insulitis.
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