Our study aimed to investigate subacute exposure to alcohol in relation to bone microstructure of mice. Animals from experimental (E) group drank a solution composed of 15 % ethanol and water for 14 days (one remodeling cycle), while those from control (C) group drank only water. In the compact bone of E group, decreased bone formation and increased porosity were observed which corresponds with lower levels of serum alkaline phosphatase and glutathione. Alcohol significantly increased sizes of primary osteon's vascular canals and decreased those of secondary osteons, Haversian canals. Relative bone volume, bone mineral density (BMD), relative bone volume without marrow cavity were also lower in E group. On the contrary, trabecular bone microstructure did not differ significantly between E and C groups. Liver function test showed higher levels of alanine aminotransferase, aspartate aminotransferase in alcohol-fed mice. Serum calcium, phosphate were significantly lower in E group. According to our study, only changes in compact bone microstructure of mice following one remodeling cycle were observed due to both direct and indirect effects of alcohol.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.33549/physiolres.933864 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Automatic segmentation of cortical bone microstructure: Application and analysis of three proximal femur sites.
Bone
January 2025
ARTORG Centre for Biomedical Engineering Research, University of Bern, Bern, Switzerland.
Osteoporosis is the most common bone metabolic unbalance, leading to fragility fractures, which are known to be associated with structural changes in the bone. Cortical bone accounts for 80 % of the skeleton mass and undergoes remodeling throughout life, leading to changes in its thickness and microstructure. Although many studies quantified the different cortical bone structures using CT techniques (3D), they are often realised on a small number of samples.
View Article and Find Full Text PDFExploring the Anti-Osteoporotic Effects of -Hexane Fraction from Nakai: Activation of Runx2 and Osteoblast Differentiation In Vivo.
Pharmaceuticals (Basel)
January 2025
Smart Farm Research Center, Korean Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea.
Background: Osteoporosis is characterized by the microstructural depletion of bone tissue and decreased bone density, leading to an increased risk of fractures. Nakai, an endemic species of the Korean Peninsula, grows wild in Ulleungdo. In this study, we aimed to investigate the effects of and its components on osteoporosis.
View Article and Find Full Text PDFDevelopment of Tailored Porous Ti6Al4V Materials by Extrusion 3D Printing.
Materials (Basel)
January 2025
Universidad Autónoma de Coahuila, Facultad de Ingeniería Mecánica y Eléctrica Unidad Norte, Monclova 25720, Coahuila, Mexico.
Nowadays, metallic bone replacement is in high demand due to different issues, like sicknesses and accidents. Thus, bone implants are fabricated with tailored properties and microstructure for long-term use in the human body. To improve such implants, 3D printing is the most promising technique.
View Article and Find Full Text PDFFour-Dimensional Printing of β-Tricalcium Phosphate-Modified Shape Memory Polymers for Bone Scaffolds in Osteochondral Regeneration.
Materials (Basel)
January 2025
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University Olomouc, 779 00 Olomouc, Czech Republic.
The use of scaffolds for osteochondral tissue regeneration requires an appropriate selection of materials and manufacturing techniques that provide the basis for supporting both cartilage and bone tissue formation. As scaffolds are designed to replicate a part of the replaced tissue and ensure cell growth and differentiation, implantable materials have to meet various biological requirements, e.g.
View Article and Find Full Text PDFAccelerated Method for Determining the Fatigue Limit of Trabecular Bone.
Materials (Basel)
January 2025
Faculty of Mechanical Engineering, Bydgoszcz University of Science and Technology, Kaliskiego 7, 85-796 Bydgoszcz, Poland.
This paper presents an experimental method for estimating the fatigue limit of trabecular bone using a single trabecular bone sample, the microstructural parameters of which were determined by microCT. Fatigue tests were carried out using the Locati method, with stepwise increasing load amplitude. The fatigue limits of the trabecular structures were determined experimentally in accordance with Miner's law of fatigue damage accumulation, based on the parameters of the reference S-N curve taken from the literature.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!