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The Role of Extracellular Vesicles Derived from MicroRNA-146a-modified Mesenchymal Stem Cells in Modulating Inflammation in Experimental Glenohumeral Osteoarthritis.
Iran J Allergy Asthma Immunol
October 2024
The Second Department of Joint, The Third Hospital of Shijiazhuang, Shijiazhuang, China.
Glenohumeral osteoarthritis (GOA) is characterized by chronic inflammation leading to joint damage. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are promising therapies because of their immunomodulatory functions. The anti-inflammatory effects of EVs from human Adipose-derived MSCs (hADSCs) overexpressing microRNA (miR)-146a were investigated in experimental GOA in this study.
View Article and Find Full Text PDF[Mechanism of Tongfu Lifei decoction inhibiting the programmed death-1/programmed death-ligand 1 signaling pathway in THP-1 cells by regulating microRNA-146a].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
October 2024
Department of Critical Care Medicine, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, Guizhou, China.
Article Synopsis
- *Methods*: An in vitro model of inflammation was created using THP-1 cells treated with LPS, and various concentrations of TFL were tested for their non-toxic effects on these cells. ELISA and RT-PCR techniques were used to measure inflammatory markers and microRNA expressions.
- *Findings*: The results indicated that the maximum non-toxic dose of TFL (0.04 mL/mL) effectively reduced the inflammation markers TNF-α and IL-6, and revealed the involvement of
Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants.
Biomaterials
March 2025
University of Maryland, Department of Nutrition and Food Science, College Park, MD, 20742, USA. Electronic address:
Article Synopsis
- The body's reaction to implanted materials can cause problems, known as the foreign body response (FBR), affecting how well the implants work.
- Researchers studied tiny molecules called microRNAs, specifically miR-146a, to understand how they influence the body's response to these implants.
- They found that miR-146a helps control inflammation and other reactions, suggesting that adjusting its levels could help make implants safer and more compatible with the body.
The role of microRNAs in atopic dermatitis.
Noncoding RNA Res
December 2024
Department of Pathobiology and Laboratory Sciences, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Atopic dermatitis (AD), known as eczema, is a chronic inflammatory skin condition affecting millions worldwide. This abstract provides an overview of the clinical features and underlying pathogenesis of AD, highlighting the role of specific microRNAs (miRNAs) in its development and progression. AD presents with distinct clinical manifestations that evolve with age, starting in infancy with dry, itchy skin and red patches, which can lead to sleep disturbances.
View Article and Find Full Text PDF[Sanshentongmai Mixture Improves Oxidative Damage in Rat Cardiomyocytes H9C2 via Upregulation of microRNA-146a].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2024
（ 100010） Department of Health Care for Cadres, Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University, Beijing 100010, China.
Objective: To investigate the effect of Sanshentongmai (SSTM) mixture on the regulation of oxidative damage to rat cardiomyocytes (H9C2) through microRNA-146a and its mechanism.
Methods: H9C2 were cultured , HO was used as an oxidant to create an oxidative damage model in H9C2 cells. SSTM intervention was administered to the H9C2 cells.
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