AI Article Synopsis
- Tuberculosis (TB) and diabetes mellitus Type 2 (DM2) are both ancient diseases that significantly impact human health, with their outcomes influenced by individual immune and metabolic responses.
- The prevalence of DM2 is rising due to factors like environment and lifestyle, and it has been identified as a major risk factor for TB infection and reactivation.
- Metabolomics, particularly mass spectrometry-based methods, is a crucial tool for discovering biomarkers that can aid in the diagnosis and understanding of TB in individuals with diabetes.
Article Abstract
Tuberculosis (TB) and diabetes mellitus Type 2 (DM2) are two diseases as ancient as they are harmful to human health. The outcome for both diseases in part depends on immune and metabolic individual responses. DM2 is increasing yearly, mainly due to environmental, genetic and lifestyle habits. There are multiple evidence that DM2 is one of the most important risk factor of becoming infected with TB or reactivating latent TB. Mass spectrometry-based metabolomics is an important tool for elucidating the metabolites and metabolic pathways that influence the immune responses to M. tuberculosis infection during diabetes. We provide an up-to-date review highlighting the importance and benefit of metabolomics for identifying biomarkers as candidate molecules for diagnosis, disease activity or prognosis.
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| http://dx.doi.org/10.2217/bmm-2018-0050 | DOI Listing |
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