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Procalcitonin Guided Therapy in Pediatric Sepsis: Do We Have the Answer?
Indian J Pediatr
December 2024
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Two-transcript signature for differentiation and clinical outcomes in severe fever with thrombocytopenia syndrome (SFTS) patients: a double-blind, multicenter, validation study.
J Clin Microbiol
December 2024
Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate that is often underdiagnosed due to the limitations of current laboratory testing. Timely diagnosis and early identification of severe cases are crucial to improving patient outcomes and overall survival rates. This study aimed to evaluate the efficacy of two transcripts, IFI44L and PI3, in the early differentiation between SFTS virus (SFTSV) infection and bacterial sepsis, as well as in the prompt identification of severe cases during epidemic seasons.
View Article and Find Full Text PDFThe Critical Lens: It is time to start using the right test for febrile young infants.
Paediatr Child Health
November 2024
Department of Biostatistics, Epidemiology and Occupational Health, McGill University, Montreal, Quebec, Canada.
Fever among infants in the first months of life is a common clinical conundrum facing all clinicians who treat children. Most well-appearing febrile young infants have viral illnesses. However, it is critical to identify those at risk of invasive bacterial infections, specifically bacteremia and bacterial meningitis.
View Article and Find Full Text PDFClinical and Analytical Performance Evaluation of an Automated Procalcitonin Assay.
J Appl Lab Med
December 2024
Department of Clinical Affairs, QuidelOrtho Corporation, Raritan, NJ, United States.
Article Synopsis
- The study assessed the effectiveness of the Vitros® PCT assay in evaluating procalcitonin (PCT) levels for guiding antibiotic therapy and assessing risk in patients with lower respiratory infections or sepsis.
- Results showed that Vitros PCT closely matched the KRYPTOR PCT assay, with a high correlation and precision, indicating reliable performance for clinical decision-making regarding sepsis.
- Findings suggested that changes in PCT levels over the first four days could predict 28-day mortality rates in patients with severe sepsis, highlighting the assay's value in clinical risk assessment.
Procalcitonin-guided use of antibiotic in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease: a randomized clinical trial.
Clin Microbiol Infect
December 2024
National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China. Electronic address:
Objectives: The objectives of this study are to analyse the effect and safety of procalcitonin (PCT)-guided antibiotic therapy in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods: We conducted a multicentre, open-label, randomized controlled trial amongst patients hospitalized for AECOPD in six hospitals in China. Enrolled patients were randomly assigned to either the PCT-guided group or the Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy-guided group.
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