AI Article Synopsis
- GABA levels measured with Magnetic Resonance Spectroscopy have a significant correlation with behavioral performance, indicating region and function-specific relationships.
- In this study, researchers examined the correlation of GABA levels in the left and right sensorimotor cortex of 24 participants, finding a strong positive correlation of 0.64.
- The correlation in GABA levels between these regions is not influenced by differences in tissue composition, suggesting that functional similarities drive these individual variations.
Article Abstract
Differences in γ-aminobutyric acid (GABA) levels measured with Magnetic Resonance Spectroscopy have been shown to correlate with behavioral performance over a number of tasks and cortical regions. These correlations appear to be regionally and functionally specific. In this study, we test the hypothesis that GABA levels will be correlated within individuals for functionally related regions-the left and right sensorimotor cortex. In addition, we investigate whether this is driven by bulk tissue composition. GABA measurements using edited MRS data were acquired from the left and right sensorimotor cortex in 24 participants. T1-weighted MR images were also acquired and segmented to determine the tissue composition of the voxel. GABA level is shown to correlate significantly between the left and right regions ( = 0.64, < 0.03). Tissue composition is highly correlated between sides, but does not explain significant variance in the bilateral correlation. In conclusion, individual differences in GABA level, which have previously been described as functionally and regionally specific, are correlated between homologous sensorimotor regions. This correlation is not driven by bulk differences in voxel tissue composition.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164430 | PMC |
| http://dx.doi.org/10.3390/biomedicines6030080 | DOI Listing |
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