Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity.
Sci Adv
January 2025
Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
A major limiting factor in the success of chimeric antigen receptor (CAR) T cell therapy for the treatment of solid tumors is targeting tumor antigens also found on normal tissues. CAR T cells against GD2 induced rapid, fatal neurotoxicity because of CAR recognition of GD2 normal mouse brain tissue. To improve the selectivity of the CAR T cell, we engineered a synthetic Notch receptor that selectively expresses the CAR upon binding to P-selectin, a cell adhesion protein overexpressed in tumor neovasculature.
View Article and Find Full Text PDFCofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions.
PLoS Pathog
January 2025
Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
Prion diseases, particularly sporadic cases, pose a challenge due to their complex nature and heterogeneity. The underlying mechanism of the spontaneous conversion from PrPC to PrPSc, the hallmark of prion diseases, remains elusive. To shed light on this process and the involvement of cofactors, we have developed an in vitro system that faithfully mimics spontaneous prion misfolding using minimal components.
View Article and Find Full Text PDFObservational studies on per- and polyfluoroalkyl substance toxicity in marine species: hints for the extrapolation of a screening value.
Environ Toxicol Chem
January 2025
Centro di Referenza Nazionale per l'Analisi e Studio di Correlazione tra Ambiente, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Italy.
A statistical procedure has been developed to derive a screening value from an observational study related to the developmental toxicity observed in loggerhead turtle (Caretta caretta) eggs exposed to long chain per- and polyfluoroalkyl substances (PFAS). A dataset of 41 nests in which the hatching rate was inversely correlated with the increase in the PFAS concentration in unhatched eggs was processed via a categorical regression approach. After outliers identification and removal, categorical regression analysis tested the relationships of the outcomes with the following parameters: perfluoro-nonanoic (PFNA), decanoic (PFDA), undecanoic (PFUdA), and dodecanoic (PFDoA) acids; perfluoroctansulfonate (PFOS); polychlorobiphenyls (PCBs) 28, 52, 101, 138, 153, 180; lead (Pb), total mercury (Hgtot), and cadmium (Cd); and other factors, such as "nest site," "clutch size," "incubation duration," and "nest minimum depth," as confounders/modifiers of the hatching rate.
View Article and Find Full Text PDFAdvancing bat monitoring: Assessing the impact of unmanned aerial systems on bat activity.
PLoS One
January 2025
Department of Competence Center for Renewable Energies and Energy Efficiency, Hamburg University of Applied Sciences, Hamburg, Germany.
With the increasing height and rotor diameter of wind turbines, bat activity monitoring within the risk area becomes more challenging. This study investigates the impact of Unmanned Aerial Systems (UAS) on bat activity and explores acoustic bat detection via UAS as a new data collection method in the vicinity of wind turbines. We tested two types of UAS, a multicopter and a Lighter Than Air (LTA) UAS, to understand how they may affect acoustically recorded and analyzed bat activity level for three echolocation groups: Pipistrelloid, Myotini, and Nyctaloid.
View Article and Find Full Text PDFTetracycline and chloramphenicol exposure induce decreased susceptibility to tigecycline and genetic alterations in AcrAB-TolC efflux pump regulators in Escherichia coli and Klebsiella pneumoniae.
PLoS One
January 2025
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Tigecycline (Tgc), a third-generation tetracycline is found as the last line of defense against multi-drug resistant bacteria. Recent increased rate of resistance to tgc, a human-restricted agent among animal bacteria poses a significant global health challenge. Overuse of first generation tetracyclines (Tet) and phenicols in animals have been suggested to be associated with Tgc resistance development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!