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Three Decades of Chloride Intracellular Channel Proteins: From Organelle to Organ Physiology. | LitMetric

AI Article Synopsis

  • Intracellular organelles are essential for cell health and function, requiring strict regulation of ionic concentrations to prevent disruptions in processes like energy production and signaling.
  • Imbalances in ions can negatively impact mitochondria, lysosomes, nuclei, and the endoplasmic reticulum, highlighting the importance of maintaining ionic homeostasis.
  • Chloride intracellular channel proteins (CLICs) are key non-canonical ion channels involved in this regulation, existing in different forms and serving both enzymatic and channel functions within the cell.

Article Abstract

Intracellular organelles are membranous structures central for maintaining cellular physiology and the overall health of the cell. To maintain cellular function, intracellular organelles are required to tightly regulate their ionic homeostasis. Any imbalance in ionic concentrations can disrupt energy production (mitochondria), protein degradation (lysosomes), DNA replication (nucleus), or cellular signaling (endoplasmic reticulum). Ionic homeostasis is also important for volume regulation of intracellular organelles and is maintained by cation and anion channels as well as transporters. One of the major classes of ion channels predominantly localized to intracellular membranes is chloride intracellular channel proteins (CLICs). They are non-canonical ion channels with six homologs in mammals, existing as either soluble or integral membrane protein forms, with dual functions as enzymes and channels. Provided in this overview is a brief introduction to CLICs, and a summary of recent information on their localization, biophysical properties, and physiological roles. © 2018 by John Wiley & Sons, Inc.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060641PMC
http://dx.doi.org/10.1002/cpph.36DOI Listing

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