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Novel Growth Factor Combination for Improving Rotator Cuff Repair: A Rat In Vivo Study.
Am J Sports Med
March 2022
Bone and Joint Laboratory, School of Medicine, University of Auckland, Auckland, New Zealand.
Background: The lack of healing at the repaired tendon-bone interface is an important cause of failure after rotator cuff repair. While augmentation with growth factors (GFs) has demonstrated promise, the ideal combination must target all 3 tissue types at the tendon-bone interface.
Hypothesis: The GF combination of transforming growth factor beta 1, Insulin-like growth factor 1, and parathyroid hormone will promote tenocyte proliferation and differentiation and improve the biomechanical and histological quality of the repaired tendon-bone interface.
Proteoglycans and Diseases of Soft Tissues.
Adv Exp Med Biol
November 2021
Department of Pathology, College of Veterinary Medicine, and Department of Basic Sciences, AU/UGA Medical Partnership, The University of Georgia, Athens, GA, USA.
Proteoglycans consist of protein cores to which at least one glycosaminoglycan chain is attached. They play important roles in the physiology and biomechanical function of tendons, ligaments, cardiovascular system, and other systems through their involvement in regulation of assembly and maintenance of extracellular matrix, and through their participation in cell proliferation together with growth factors. They can be divided into two main groups, small and large proteoglycans.
View Article and Find Full Text PDFUtrophin modulator drugs as potential therapies for Duchenne and Becker muscular dystrophies.
Neuropathol Appl Neurobiol
October 2021
Neuromuscular Disorders, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Utrophin is an autosomal paralogue of dystrophin, a protein whose deficit causes Duchenne and Becker muscular dystrophies (DMD/BMD). Utrophin is naturally overexpressed at the sarcolemma of mature dystrophin-deficient fibres in DMD and BMD patients as well as in the mdx Duchenne mouse model. Dystrophin and utrophin can co-localise in human foetal muscle, in the dystrophin-competent fibres from DMD/BMD carriers, and revertant fibre clusters in biopsies from DMD patients.
View Article and Find Full Text PDFTranscriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth†.
Biol Reprod
March 2021
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Approximately, 25% of all preterm births are due to preterm premature rupture of membranes. Mice deficient in proteoglycans biglycan (Bgn) and decorin (Dcn) display abnormal fetal membranes and increased incidence of preterm birth. We conducted RNA-Seq to profile fetal membranes and identify molecular pathways that may lead to preterm birth in double knockout (DKO) mice (Bgn-/-; Dcn-/-) compared to wild-type (WT) at two different gestational stages, E12 and E18 (n = 3 in each group).
View Article and Find Full Text PDFProteoglycans and dental biology: the first review.
Carbohydr Polym
December 2019
Departamento de Ortodontia da Universidade Guarulhos, Praça Tereza Cristina, 229, Guarulhos, SP, P.O. Box 07023-070 Brazil. Electronic address:
Proteoglycans (PGs) are proteins which are vital components located in the extracellular matrix, cell surface or intracellular granules. They are linked to polysaccharides called glycosaminoglycans. There are several aspects associated with PGs, such as cell signaling and organization of the extracellular matrix (ECM), making them pivotal participants in many tissue compositions.
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