Purpose: The human pineal gland is a small neuroendocrine organ which produces melatonin. The main goal of this study was to provide a reference range for pineal volume in all age groups and to determine calcified and noncalcified tissue and their proportions, which may be a reflection of melatonin production in all age groups, by using very thin computerized tomography (CT) slices.
Materials And Methods: A total of 167 outpatients had undergone cranial CT. Each of the subject's total pineal volume (TPV), calcified pineal volume (CPV) and noncalcified pineal volume (NPV) according to age groups were calculated in cubic millimeters. Also, proportion of calcification (POC) was noted.
Results: The median values were 88.5 mm (12.3 mm-411mm) for TPV, 74.3 mm (12.3 mm-298 mm) for NPV, and 3.9 mm (0 mm-141 mm) for CPV. POC showed a gradual increase from 0-49 years. In the ≥70 group, when compared with the 60-69 age group, CPV and POC values were significantly lower (P: 0.036, P: 0.034, respectively).
Conclusion: This study brings a radiological point of view to the distribution of pineal calcification according to age that has a link with melatonin secretion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854269 | PMC |
| http://dx.doi.org/10.5334/jbr-btr.892 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dysregulation of the molecular clock by blood-borne factors in Alzheimer's disease patients.
J Neurol
January 2025
Department of Central laboratory, Xuanwu Hospital of Capital Medical University, Beijing, 100053, P.R. China.
Background: Circadian disruptions are increasingly recognized in Alzheimer's disease (AD) patients and may influence disease onset and progression. This study examines how AD pathology affects blood-borne factors that regulate circadian rhythms.
Methods: Eighty-five participants from the Sino Longitudinal Study on Cognitive Decline were enrolled: 35 amyloid-beta negative normal controls (Aβ- NCs), 23 amyloid-beta positive normal controls (Aβ+ NCs), 15 patients with amnestic mild cognitive impairment (aMCI), and 12 with Alzheimer's disease dementia (ADD).
Correction to 'Pineal Gland Volume in Children With Intellectual Disability'.
Int J Dev Neurosci
February 2025
Using a chronic unpredictable mild stress (CUMS) combined with multi-platform water environment sleep deprivation (SD) as an animal model, the occurrence and development of human depression combined with insomnia were simulated. The abnormal mitochondrial autophagy signaling caused by the putative kinase 1/Parkin E3 ubiquitin protein ligase (Pink1/Parkin) signaling pathway directly affects the normal secretion of melatonin by the pineal gland, which may explain the pathogenesis of depression combined with insomnia. This study aims to explore the depression-like behavior, sleep changes, central oxidative stress response, pineal mitochondrial autophagy damage, melatonin secretion, histopathological changes of the pineal gland, and the expression of Pink1/Parkin signaling-related factors in CUMS+SD rats.
View Article and Find Full Text PDFPineal gland volume in children with intellectual disability.
Int J Dev Neurosci
December 2024
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Kahramanmaras SutcuImam University, Kahramanmaras, Turkey.
Objective: Pineal gland volume (PGV), which is associated with sleep and circadian rhythm, is known to be changed in some psychiatric disorders such as major depression, mood disorders and schizophrenia. This study aimed to compare the PGV of children with mild and moderate intellectual disability (ID) and healthy children.
Methods: This multicentre retrospective study included 40 children with ID (patient group), aged 6-12 years and 40 age- and sex-matched healthy children (control group).
Investigation of the relationship of sleep disorder occurring in fibromyalgia with central nervous system and pineal gland volume.
Acta Neuropsychiatr
November 2024
Department of Biostatistics and Medical Information, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, Türkiye.
Objective: Mechanisms of sleep disorders in fibromyalgia (FM) patients, such as insomnia, early morning awakenings and poor quality sleep, have not yet been proven and no consistent and effective treatment is yet available. The aim of this study was to investigate the pineal gland volume and the relationship between total fibre count, total fibre volume and total fibre length of the spinoreticular tract involved in regulation of sleep and wakefulness in terms of the mechanism of sleep disturbance.
Methods: This study included only female cases, 31 with fibromyalgia and 31 controls.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!