In this study, the co-culture of and , the endophytes in the seeds of , were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by against its co-culture fungus, , and common pathogens exhibited competitive interaction in this mix-culture. Compounds and showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM.
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| http://dx.doi.org/10.3390/molecules23071816 | DOI Listing |
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