This study aimed at identification and characterization of a novel multidrug-resistant Pseudomonas putida strain Guangzhou-Ppu420 carrying two copies of qnrVC6 isolated from a hospital in Guangzhou, China, in 2012. Antimicrobial susceptibility was tested by Vitek2™ Automated Susceptibility System and Etest™ strips, and whole-genome sequencing facilitated analysis of its multidrug resistance. The genome has a length of 6,031,212 bp and an average G + C content of 62.01%. A total of 5,421 open reading frames were identified, including eight 5S rRNA, seven 16S rRNA, and seven 23S rRNA, and 76 tRNA genes. Importantly, two copies of qnrVC6 gene with three ISCR1 around, a bla carrying integron In528, a novel gcu173 carrying integron In1348, and six antibiotic resistance genes were identified. This is the first identification of two copies of the qnrVC6 gene in a single P. putida isolate and a class 1 integron In1348.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/mdr.2018.0104 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An XDR Pseudomonas aeruginosa ST463 Strain with an IncP-2 Plasmid Containing a Novel Transposon Tn Encoding and and a Second Plasmid with Two Copies of .
Microbiol Spectr
February 2023
Department of Critical care medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, China.
Article Synopsis
- The rise of carbapenem resistance in Pseudomonas aeruginosa, particularly the identification of an extensively drug-resistant (XDR) strain PA30 of sequence type ST463, poses a major global health threat.
- This strain harbors two plasmids: pPA30_1, which contains metallo-β-lactamase genes AFM-1 and IMP-45, and pPA30_2, featuring duplicated copies of other resistance genes.
- The genetic structure of pPA30_1 closely resembles another plasmid known as pHS17-127; variations in its transposons highlight potential gene transfer between different bacterial clones, facilitating the spread of resistance.
Complete Sequence of a Novel Multidrug-Resistant Pseudomonas putida Strain Carrying Two Copies of qnrVC6.
Microb Drug Resist
April 2019
4 Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland.
This study aimed at identification and characterization of a novel multidrug-resistant Pseudomonas putida strain Guangzhou-Ppu420 carrying two copies of qnrVC6 isolated from a hospital in Guangzhou, China, in 2012. Antimicrobial susceptibility was tested by Vitek2™ Automated Susceptibility System and Etest™ strips, and whole-genome sequencing facilitated analysis of its multidrug resistance. The genome has a length of 6,031,212 bp and an average G + C content of 62.
View Article and Find Full Text PDFComplete sequence of pBM413, a novel multidrug resistance megaplasmid carrying qnrVC6 and bla from pseudomonas aeruginosa.
Int J Antimicrob Agents
January 2018
Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA.
This study aimed to characterise a novel multidrug resistance megaplasmid carrying qnrVC6 and bla from Pseudomonas aeruginosa strain Guangzhou-Pae617 isolated from a patient hospitalised in Guangzhou, China, in 2012. The plasmid pBM413 has a length of 423 017 bp and an average G + C content of 56.41%.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!