PLACENTAL GROWTH FACTOR AND MATERNAL CHARACTERISTICS IN THE FIRST TRIMESTER AMONG PREGNANT WOMEN OF KAZAKH NATIONALITY.

The impact of ethnicity and maternal anamnesis data at the PLGF level is determined. The aim of our study was to estimate changes at PIGF level in the first trimester of pregnancy, depending on the maternal anamnesis data among women of Kazakh ethnicity. 63 pregnant women at 12 weeks of gestation were included into the study. All of them were examined with the maternal anamnesis data selection and a pre-gravid body mass index (BMI) was calculated. At the gestational age of 12 weeks, one sample of blood was taken to determine PlGF among tested pregnant women. The level of placental growth factor among the pregnant women under the study ranged from 0.01 to 107.4 pg/ml at 12 weeks, approximately 80% of the pregnant women had a PlGF level below 25 pg/ml. We identified no differences in PlGF level depending on age, weight, pre-gravid BMI, nulliparity, multiparity. We revealed that pregnant women with more than 4,000 grams childbirth in anamnesis had a higher concentration of PlGF (Me= 27.5 pg/ml Q1-17 Q3-63.5), compared with women whose the given factor was absent in the anamnesis (Me=14.9 pg/ml Q1-9.7 Q3-23), U=101.5, Z =-2.068, p=0.039. We assume that a low concentration of PlGF among pregnant Kazakhs can be determined by ethnic characteristics, as well as by a decrease in the adaptive capacity of adrenal hormones. We recommend that the study on the ethnic variation of PlGF among pregnant women of Kazakh nationality should be conducted completely.