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Filgrastim Use in the Treatment of Azathioprine-Induced Myelosuppression Toxicity After Prescription Error in the Feline.
J Am Anim Hosp Assoc
May 2024
From Foxboro Animal Hospital, Foxboro, MA.
Only one report on the successful use of filgrastim (granulocyte colony-stimulating factor) in cats for severe neutropenia following azathioprine toxicity exists. Here, we report on a case in which a cat was prescribed methimazole but the medication was filled incorrectly with azathioprine tablets and the prescription label indicated a methimazole dosing regimen that was administered for three days before recognition of the error. On presentation, the cat's physical examinations were consistent with previous examinations before ingestion of azathioprine.
View Article and Find Full Text PDFCrusted Scabies Presenting as Erythroderma in a Patient With Iatrogenic Immunosuppression for Treatment of Granulomatosis With Polyangiitis.
Cutis
May 2023
Yale School of Medicine, New Haven, Connecticut. Drs. Leventhal and Vesely are from the Department of Dermatology.
The diagnosis of scabies can be difficult when the infection presents as erythroderma. Crusted scabies is a severe form of scabies caused by cutaneous ectoparasitic infection by the mite Sarcoptes scabiei var hominis. Crusted scabies most commonly occurs in patients with underlying immunosuppression from acquired infection or subsequent to solid organ or bone marrow transplantation.
View Article and Find Full Text PDFCase report: polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review.
Front Pharmacol
May 2023
Department of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Article Synopsis
- Azathioprine (AZA) is used to suppress the immune system in autoimmune diseases but can cause serious side effects like myelosuppression, especially due to genetic differences in metabolism.
- The study highlights a case of a young Chinese woman with specific genetic variations who experienced severe side effects after high doses of AZA for lupus, without proper monitoring of blood cell counts.
- A systematic review of similar cases reveals patterns in blood cell changes associated with genetic variants, aiming to improve clinical management and treatment outcomes for patients on AZA.
A case of azathioprine-induced aplastic anemia.
Int J Lab Hematol
December 2022
Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Azathioprine (AZA) is an immunosuppressant that is widely used to treat many disease states including rheumatoid arthritis. We present a patient who was treated with AZA for rheumatoid arthritis and subsequently hospitalized for severe myelosuppression due to acquired aplastic anemia. Upon genetic testing it was found that the patient was thiopurine methyltransferase (TMPT) deficient, a well-documented risk factor for myelosuppression in patients taking azathioprine.
View Article and Find Full Text PDFAzathioprine-Induced Anagen Effluvium with Myelosuppression.
Skinmed
July 2022
Department of Dermatology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Article Synopsis
- Anagen effluvium and myelosuppression are uncommon side effects of the medication azathioprine.
- Hair loss from azathioprine occurs more often in transplant patients compared to those who aren't undergoing transplantation.
- The report discusses three patients who experienced hair loss and bone marrow suppression after being treated with azathioprine for skin conditions.
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