In order to assess the potential of sPLA-X as a therapeutic target for atherosclerosis, novel sPLA inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked on a lead generation effort that resulted in the identification of a novel series of indole-2-carboxamides as selective sPLA2-X inhibitors with excellent potential for further optimization.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047051 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.7b00505 | DOI Listing |
Publication Analysis
Top Keywords
discovery series
4
series indole-2
4
indole-2 carboxamides
4
carboxamides selective
4
selective secreted
4
secreted phospholipase
4
phospholipase type
4
type spla-x
4
spla-x inhibitors
4
inhibitors order
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!