Gullo's syndrome is a singular physiological phenomenon defined by an abnormal increase in serum pancreatic enzyme levels that may occur in healthy subjects in the absence of pancreatic disorders. During routine health examination in a 54-year-old postmenopausal woman with severe endometriosis, elevated values of serum amylase and lipase were fortuitously observed (198 and 1461 U/L, resp.). Over five years of regular pancreas surveillance, all clinical, biological, and imaging investigations were normal. However, the pancreatic enzyme levels have shown considerable fluctuations including some episodic transient normalization. The description of this benign pancreatic hyperenzymemia case incidentally associated with endometriosis disease is a very rare clinical situation. More in-depth documentation of this phenomenon may help clinicians to avoid unnecessary diagnostic management approaches and reassure the concerned patients that this affection would not be so worrying.
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http://dx.doi.org/10.1155/2018/6310245 | DOI Listing |
Cureus
September 2023
Internal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.
Benign pancreatic hyperenzymemia (BPH) or Gullo's syndrome is a benign condition consisting of an oscillating elevation of pancreatic enzymes without the identification of pancreatic disease. Its diagnosis is usually incidental and by excluding other conditions that occur with elevated pancreatic enzymes. To the best of our knowledge, there are no reports of this diagnosis to this day in Portugal.
View Article and Find Full Text PDFJ Assist Reprod Genet
July 2022
Reproductive Medicine Unit, ANDROS Day Surgery Clinic, Via Ausonia 43/45, 90144, Palermo, Italy.
Purpose: Ovarian hyperstimulation syndrome (OHSS) represents a rare but dangerous condition associated with controlled ovarian stimulation (COS) in IVF/ICSI. Over the last decades, many strategies have been introduced into clinical practice with the objective of preventing this potentially life-threatening condition. Among these, the freeze-all policy has gained great popularity, thanks to improvements in vitrification.
View Article and Find Full Text PDFPrz Gastroenterol
November 2020
Department of Gastroenterology with Endoscopy Unit, Medical University, Lublin, Poland.
Benign pancreatic hyperenzymemia (Gullo's syndrome) is characterized by a more than threefold increase of the serum pancreatic enzymes lipase and amylase activity in the absence of any pancreatic disease. Recently, there is an increase in describing cases of Gullo's syndrome in medical literature. Gullo's syndrome is a diagnosis of exclusion, and clinicians should be aware of various other conditions which can cause elevation of pancreatic enzymes.
View Article and Find Full Text PDFCureus
May 2020
Internal Medicine, University of Illinois College of Medicine, Peoria, USA.
Benign Pancreatic Hyperenzymemia or Gullo's Syndrome is a rare syndrome that has been identified relatively recently and is characterized by abnormally elevated serum pancreatic enzymes in the absence of any clinical or pathological evidence of pancreatic disease. It is usually discovered incidentally, occurs sporadically or as a familial form and remains a diagnosis of exclusion. Both amylase and lipase are elevated but can return to normal levels temporarily.
View Article and Find Full Text PDFLab Med
July 2020
Clinical Analysis Department, Hospital of Manacor, Manacor, Spain.
Benign pancreatic hyperenzymemia, also known as Gullo's syndrome, is a little-known syndrome first described in 1996 in patients studied for an elevation of pancreatic enzymes while otherwise being asymptomatic. We describe the case of a 2-year-old patient who was found to have significant elevation of amylase and lipase levels while he was asymptomatic. Blood tests and imaging tests were performed to determine the etiology, but they gave normal results.
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