Neuronal action potentials or spikes provide a long-range, noise-resistant means of communication between neurons. As point processes single spikes contain little information in themselves, i.e., outside the context of spikes from other neurons. Moreover, they may fail to cross a synapse. A burst, which consists of a short, high frequency train of spikes, will more reliably cross a synapse, increasing the likelihood of eliciting a postsynaptic spike, depending on the specific short-term plasticity at that synapse. Both the number and the temporal pattern of spikes in a burst provide a coding space that lies within the temporal integration realm of single neurons. Bursts have been observed in many species, including the non-mammalian, and in brain regions that range from subcortical to cortical. Despite their widespread presence and potential relevance, the uncertainties of how to classify bursts seems to have limited the research into the coding possibilities for bursts. The present series of research articles provides new insights into the relevance and interpretation of bursts across different neural circuits, and new methods for their analysis. Here, we provide a succinct introduction to the history of burst coding and an overview of recent work on this topic.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043860 | PMC |
| http://dx.doi.org/10.3389/fncom.2018.00048 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cross-Point Ferroelectric HfZrO Capacitors for Remanent Polarization-Driven In-Memory Computing.
Nano Lett
January 2025
Department of Electrical and Computer Engineering, The University of Texas at Dallas, Richardson, Texas 75080, United States.
Ferroelectric HfZrO (HZO) capacitors have been extensively explored for in-memory computing (IMC) applications due to their nonvolatility and back-end-of-line (BEOL) compatible process. Several IMC approaches using resistance and capacitance states in ferroelectric HZO have been proposed for vector-matrix multiplication (VMM), but previous approaches suffer from limited accuracy and reliability. In this work, we propose a promising approach centered on the remanent polarization (P) switching of binary ferroelectric HZO capacitor synapses.
View Article and Find Full Text PDFA global overview of shared genetic architecture between smoking behaviors and major depressive disorder in European and East Asian ancestry.
J Affect Disord
January 2025
Department of Environmental Genomics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:
Background: The co-occurrence of smoking behaviors and major depressive disorder (MDD) has been widely documented in populations. However, the underlying mechanism of this association remains unclear.
Methods: Genome-wide association studies of smoking behaviors and MDD, combined with multi-omics datasets, were usedto characterise genetic correlations, identify shared loci and genes, and explore underlying biological mechanisms.
A Medical image segmentation model with auto-dynamic convolution and location attention mechanism.
Comput Methods Programs Biomed
January 2025
School of Computer Science and Technology, Shandong Technology and Business University, Yantai 264005, China; Shandong Future Intelligent Financial Engineering Laboratory, Yantai 264005, China. Electronic address:
Background And Objective: Medical image segmentation is a technique used to identify and locate anatomical structures or diseased areas from medical images with high accuracy. Accurate image segmentation is crucial in medical applications such as clinical diagnosis, surgical planning, and treatment monitoring. It provides reliable quantitative information, which helps in making decisions.
View Article and Find Full Text PDFThe uv1 neuroendocrine cells provide mechanosensory feedback of vulval opening.
J Neurosci
January 2025
Department of Biology, University of Miami, Coral Gables, FL 33143 USA
Neuroendocrine cells react to physical, chemical, and synaptic signals originating from tissues and the nervous system, releasing hormones that regulate various body functions beyond the synapse. Neuroendocrine cells are often embedded in complex tissues making direct tests of their activation mechanisms and signaling effects difficult to study. In the nematode worm , four uterine-vulval (uv1) neuroendocrine cells sit above the vulval canal next to the egg-laying circuit, releasing tyramine and neuropeptides that feedback to inhibit egg laying.
View Article and Find Full Text PDFDistinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.
Proc Natl Acad Sci U S A
January 2025
HHMI, University of California, Davis, CA 95616.
During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this crossover patterning results from nascent recombination sites competing to accrue a limiting pro-crossover RING-domain protein (COR) that diffuses between synapsed chromosomes. Here, we delineate the localization dynamics of three mammalian CORs in the mouse and determine their interdependencies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!