Objective Of Work: The authors conducted a clinical study to evaluate the effectiveness of amitriptyline in treatment of chronic TMD patients and to compare treatment results with stabilization splint.
Materials And Methods: Twenty-one patients with chronic TMD were included and randomly distributed into 3 groups: patients in Group A received amitriptyline, patients in Group B received placebo, and those in Group C were treated with stabilization splint. Treatment outcomes (pain assessed by a visual analogue scale (VAS), maximal comfortable mouth opening (MCO) and oral health related quality of life (OHIP-14)) were taken at baseline (before treatment), and at 1, 6 and 12 week of treatment.
Results: No statistically significant differences between the groups at baseline were found (p>0.05). VAS scores improved significantly in Group A (F=11.326, p=0.002, effect size =0.791) and in group C (F=7.343, p=0.005, effect size=0.647). Mean OHIP-14 scores decreased significantly only in Group A (F=4.417, p=0.036, effect size =0.596). In Group B, VAS and OHIP-14 scores did not change significantly over time. Subjects in Group C had a significant change in MCO relative to Group A and Group B.
Conclusion: From this pilot study it can be concluded that the use of low doses of amitriptyline for a period of 12 weeks is effective for pain management and quality of life improvement in chronic TMD patients. Stabilization splint demonstrated superiority in the management of limited mouth opening during the same period.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047595 | PMC |
| http://dx.doi.org/10.15644/asc52/2/4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of chronic painful temporomandibular disorders on quality of life.
J Oral Facial Pain Headache
June 2024
Department of Surgery, University of Salamanca, 37007 Salamanca, Spain.
Temporomandibular Disorders (TMDs) are pathologies based on multifactorial etiology and a biopsychosocial model, where anxiety becomes one of the most important psychological factors as it is the most frequent symptom presented in most of the population at some point in life. Taking into account the need for a multidisciplinary approach, we set out to evaluate the possible impact of orofacial pain on patients' quality of life. In this study, the sample population FROM the Medical School of the University of Coimbra (Portugal) was evaluated using two tools: Diagnostic Criteria for Temporomandibular Disorder (DC/TMD) and an adaptation of the West Haven-Yale Multidimensional Pain Inventory.
View Article and Find Full Text PDFAxis I diagnosis profile according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD): comparison between hospital-based orofacial pain clinic and dental academic-based orofacial pain clinic.
J Oral Facial Pain Headache
December 2024
Department Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine, the Faculty of Medical and Health Sciences, Tel Aviv University, 6934228 Tel Aviv, Israel.
Temporomandibular disorder (TMD) is considered a complex disorder that follows the biopsychosocial model. The current study aimed to explore the effect of clinic location and referring physicians on the distribution of Axis I diagnoses according to the Diagnostic Criteria for TMD (DC/TMD). Eighty-eight patients from a dental school Orofacial Pain Clinic (DentalOFP) and 104 patients from a hospital Orofacial Pain Clinic (HospitalOFP) were examined by the same dentist who was certified as a DC/TMD examiner and compared.
View Article and Find Full Text PDFTell me what to expect: how instructions affect the pain response of patients with chronic myofascial pain with referral.
J Oral Facial Pain Headache
December 2024
Neuroscience of Emotion Cognition and Nociception Group (NeuroCEN Group), Faculty of Odontology, Complutense University of Madrid, 28040 Madrid, Spain.
The aims of the study are to analyze the influence of pain and no pain expectations on the physiological (electromyography (EMG) and pupillometry) and cognitive (Numerical Rating Scale (NRS)) response to pain. Pain expectation and no pain expectation situations were induced by employing instructional videos. The induction of pain was performed by palpating the masseter with an algometer in a sample of 2 groups: 30 healthy participants (control group) and 30 patients (Temporomandibular disorders (TMD) group) with chronic myofascial pain with referral in the masseter muscle (Diagnostic Criteria for Temporomandibular Dissorders (DC/TMD)).
View Article and Find Full Text PDFPrevalence of central sensitization and somatization in adults with temporomandibular disorders-a prospective observational study.
J Oral Facial Pain Headache
December 2024
Department of Experimental Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
Temporomandibular disorders (TMD) comprise a group of conditions affecting the masticatory muscles, the temporomandibular joints and associated structures, often manifesting as orofacial pain and functional limitations of the mandible. Central sensitization (CS) is gaining increasing attention in research focused on pain syndromes and somatization, playing a significant role in the pain experience. This study investigates the prevalence of CS and somatization among TMD patients, analyzing their relationships with TMD diagnoses and the intensity of chronic masticatory muscle pain (MMP).
View Article and Find Full Text PDFThe effects of socioeconomic position on endogenous pain modulation: A quasi-experimental approach.
J Pain
January 2025
Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, USA; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, USA; Department of Anesthesiology and Psychiatry, University of Maryland School of Medicine, Baltimore, USA; Placebo Beyond Opinions Center, University of Maryland School of Nursing, Baltimore, USA. Electronic address:
Socioeconomic Position (SEP) is a multidimensional construct encompassing education, income, occupation, and neighborhood distress, influencing chronic pain severity, interference, and duration. However, its impact on placebo analgesia, where reduced pain perception occurs due to treatment belief, remains understudied. Using a quasi-experimental approach, we investigated SEP's influence on placebo analgesia in 401 participants with temporomandibular disorder (TMD) and 400 pain-free individuals.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!