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Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT.
Neurology
February 2025
Section on Gerontology and Geriatric Medicine, Department of Internal Medicine and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, NC.
Background And Objectives: The Systolic Blood Pressure Intervention Trial suggested that intensive lowering of systolic blood pressure (SBP) decreases the risk of developing dementia. However, an insufficient number of probable dementia cases stemming from the trial's early termination made results inconclusive. The goal of this study was to estimate the effect of intensive vs standard SBP lowering on the longer term incidence of cognitive impairment leveraging extended follow-up for cognitive status.
View Article and Find Full Text PDFJanus LAAM-loaded electrospun fibrous buccal films for treating opioid use disorder.
Biomaterials
December 2024
Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, 23298, USA; Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA, 23298, USA; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, 23298, USA; Center for Pharmaceutical Engineering, Center for Drug Discovery, Department of Pediatrics, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address:
The opioid crisis has claimed approximately one million lives in the United States since 1999, underscoring a significant public health concern. This surge in opioid use disorder (OUD) fatalities necessitates improved therapeutic options. Current OUD therapies often require daily clinical visits, leading to poor patient compliance and high costs to the health systems.
View Article and Find Full Text PDFLong-term effects of endometrial resection or ablation in combination with levonorgestrel intrauterine device on bleeding patterns.
Arch Gynecol Obstet
December 2024
Department of Obstetrics and Gynecology, Odense University Hospital, Kløvervænget 23, 5000, Odense, Denmark.
Objective: Endometrial resection and ablation are minimal invasive surgeries used to treat women with abnormal uterine bleeding (AUB). Both may be followed by a high reoperation rate up to 24%. However, some studies suggest that this may be improved by adding a levonorgestrel intrauterine device (LNG-IUD) immediately following surgery.
View Article and Find Full Text PDFTotal arsenic and inorganic arsenic in Myanmar rice.
Heliyon
December 2024
Department of Earth and Environmental Sciences and Williamson Research Centre for Molecular Environmental Sciences, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, M13 9PL, United Kingdom.
Myanmar is a major rice exporter. Rice is an important source of nourishment for its population. However, rice can be contaminated with toxic elements, including arsenic, long-term exposure to which has been linked to several illnesses, including cancer.
View Article and Find Full Text PDFStability of the thromboxane B biomarker of low-dose aspirin pharmacodynamics in human whole blood and in long-term stored serum samples.
Res Pract Thromb Haemost
November 2024
Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Background: Serum thromboxane B (sTXB) is a validated biomarker of low-dose aspirin pharmacodynamics. In the original method, nonanticoagulated blood samples must be incubated at 37 °C immediately after withdrawal, centrifuged and serum supernatant should be frozen until assayed. Timely completion of all preanalytical steps may affect the feasibility and quality of sTXB measurements.
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