AI Article Synopsis
- Preeclampsia (PE) is linked to inflammation and changes in blood vessel function, which can lead to reduced blood flow to the placenta; NLR and PMR may help predict its onset.
- A study analyzed records from 110 hospitalized pregnant women, separating them into two groups: those who developed PE and those who did not.
- Findings showed that higher NLR and PMR values were significantly associated with the development of PE, suggesting they could serve as useful markers for monitoring at-risk patients.
Article Abstract
Introduction: The appearance of preeclampsia (PE) would comprise the alteration of endothelial function and activation of the inflammatory response, leading to placental hypoperfusion. The neutrophil/lymphocyte ratio (NLR) and the polymorphonuclear/monomorphonuclear ratio (PMR) could measure the underlying inflammatory component and predict the onset of the disorder.
Material And Methods: Observational, analytical, case and control study. We retrospectively analysed medical records of pregnant women, hospitalized for hypertension registers. The patients were divided into Group1=with PE development, and Group2=without PE development.
Results: 110 patients were included: Group1=58.2% and Group2=41.8%, observing differences between the NLR means (P=.01) and PMR means (P=.02). An NLR ≥4.5 (P=.002; OR=3.9; 95%CI=1.6-9.5) and a PMR ≥3 (P=.004; OR=3.5; 95%CI=1.4-8.4) was related with PE.
Conclusion: The elevation of NLR and PMR in hypertensive pregnant patients, could be considered indicators for the development of PE.
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| http://dx.doi.org/10.1016/j.hipert.2018.06.001 | DOI Listing |
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