The pathogenesis of pediatric rheumatologic conditions varies with the specific disorder; however, certain commonalities are seen: altered migration of cells into tissues, production of inflammatory mediators, and enhanced activation of cells. Autoantibodies signal loss of tolerance and B and T cells may be seen on pathologic evaluation. Neutrophils are commonly observed in tissues for many diseases and are recruited through the activation of endothelial cells. These cellular infiltrates define the inflammatory response character and in some cases provide a therapeutic framework. Increased knowledge of the interactions of these cells and their products allow targeted treatments for rheumatic diseases.
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