AI Article Synopsis
- The study evaluates liver cancer incidence rates and risk factors among non-Hispanic American Indian/Alaska Native (AI/AN) populations from 1999 to 2009.
- It found that AI/AN individuals had significantly higher liver cancer rates compared to white populations, with an overall rate of 11.5 per 100,000 versus 4.8 per 100,000.
- Key risk factors such as alcohol use and obesity were strongly correlated with liver cancer incidence, revealing a need for targeted interventions to lower these risks in the AI/AN community.
Article Abstract
Purpose: To evaluate liver cancer incidence rates and risk factor correlations in non-Hispanic AI/AN populations for the years 1999-2009.
Methods: We linked data from 51 central cancer registries with the Indian Health Service patient registration databases to improve identification of the AI/AN population. Analyses were restricted to non-Hispanic persons living in Contract Health Service Delivery Area counties. We compared age-adjusted liver cancer incidence rates (per 100,000) for AI/AN to white populations using rate ratios. Annual percent changes (APCs) and trends were estimated using joinpoint regression analyses. We evaluated correlations between regional liver cancer incidence rates and risk factors using Pearson correlation coefficients.
Results: AI/AN persons had higher liver cancer incidence rates than whites overall (11.5 versus 4.8, RR = 2.4, 95% CI 2.3-2.6). Rate ratios ranged from 1.6 (Southwest) to 3.4 (Northern Plains and Alaska). We observed an increasing trend among AI/AN persons (APC 1999-2009 = 5%). Rates of distant disease were higher in the AI/AN versus white population for all regions except Alaska. Alcohol use (r = 0.84) and obesity (r = 0.79) were correlated with liver cancer incidence by region.
Conclusions: Findings highlight disparities in liver cancer incidence between AI/AN and white populations and emphasize opportunities to decrease liver cancer risk factor prevalence.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108913 | PMC |
| http://dx.doi.org/10.1007/s10552-018-1059-3 | DOI Listing |
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