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Long-term renal outcomes of children with cancers treated with platinum-based chemotherapy: A retrospective chart analysis.
Pediatr Blood Cancer
January 2025
Department of Nephrology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Purpose: Platinum-based chemotherapy is a mainstay of treatment for many childhood cancers but is associated with acute nephrotoxicity and long-term ototoxicity. There is emerging evidence of long-term renal complications. This study aimed to assess the prevalence of chronic kidney disease (CKD) in children treated with platinum chemotherapy (cisplatin and carboplatin) and identify potential risk factors for the development of CKD.
View Article and Find Full Text PDFEpidemiology and survival of primary intracranial malignant tumor patients with drop metastasis: a population-based analysis.
Acta Neurochir (Wien)
October 2024
Department of Neurosurgery, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, Jilin, P.R. China.
Article Synopsis
- Drop metastasis in primary intracranial malignant tumors affects patient survival, with the study analyzing data from the SEER database to understand its epidemiology and prognosis.
- Out of 56,839 cases studied, only 792 had drop metastasis, indicating a low rate of 1.4%, primarily affecting children under ten, with embryonal/primitive/medulloblastoma showing the highest rate of 11.6%.
- The study found that tumors in the infratentorial space had a higher drop metastasis risk, and routine complete treatment significantly improves survival outcomes for affected patients.
Craniospinal irradiation using pencil beam Scanning: The PSI experience.
Phys Med
November 2024
Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland; Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Radiation Oncology, University Hospital of Zürich, Zürich, Switzerland.
Article Synopsis
- The study evaluated craniospinal irradiation (CSI) treatments using protons at the Paul Scherrer Institute, focusing on local recurrences and late toxicity outcomes for 71 patients, mostly children and young adults with tumors like medulloblastoma and ependymoma.
- Data from patients treated in both prone and supine positions were analyzed, revealing that supine positioning led to lower systematic and random errors in treatment setup, resulting in more accurate dosing.
- The research concluded that local failures in treatment were not linked to inaccuracies in radiation dosing, and there was no observed correlation between treatment-related toxicities and increased radiation effects.
Unlocking delays: revealing barriers to early diagnosis of childhood central nervous system tumors in an upper-middle-income country.
Childs Nerv Syst
November 2024
Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil.
Purpose: Childhood central nervous system (CNS) tumors tend to have a longer time interval until diagnosis than other pediatric malignancies. The aim is to describe the time to diagnosis among Brazilian pediatric patients treated at a tertiary center and explore associated factors.
Methods: Cross-sectional study; application of questionnaires to parents of children with CNS tumors during outpatient visit or inpatient care.
Symptomatic cerebral vasospasm after posterior fossa surgery in pediatric patients: single-center study and systematic literature review.
Childs Nerv Syst
December 2024
Department of Pediatric Neurosurgery, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Article Synopsis
- The study investigates symptomatic vasospasm in pediatric patients who had surgery on the posterior fossa, noting that it’s a rare complication primarily linked to subarachnoid hemorrhage.
- One patient out of 178 developed symptomatic diffuse vasospasm post-surgery, and literature reviews found only 9 additional cases involving various intra- and extra-axial lesions.
- The findings suggest that while iatrogenic vasospasm in children post-surgery is uncommon, outcomes can vary widely, and more awareness is needed among medical professionals regarding this complication, though definitive risk factors remain unclear due to the limited number of cases.
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