A novel -phragmalin-type limonoid, named carapanosin D (), and two novel mexicanolide-type limonoids, carapanosins E (2) and F (), were isolated from the seed oil of andiroba A), a traditional medicine in Brazil and Latin American countries. Their structures were unambiguously determined on the basis of spectroscopic analyses using one-dimensional (1D) and two-dimensional (2D) NMR techniques and High resolution Fast Atom Bombardment Mass Spectrometry (HRFABMS). Compounds ⁻ were evaluated for their effects on the production of nitric oxide (NO) in Lipopolysaccharide (LPS)-activated mouse peritoneal macrophages. The NO inhibitory assay suggested that compounds and have high potency as inhibitors of macrophage activation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099744 | PMC |
| http://dx.doi.org/10.3390/molecules23071778 | DOI Listing |
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Carapanosins D-F from the Seeds of Andiroba (, Meliaceae) and Their Effects on LPS-Activated NO Production.
Molecules
July 2018
Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
A novel -phragmalin-type limonoid, named carapanosin D (), and two novel mexicanolide-type limonoids, carapanosins E (2) and F (), were isolated from the seed oil of andiroba A), a traditional medicine in Brazil and Latin American countries. Their structures were unambiguously determined on the basis of spectroscopic analyses using one-dimensional (1D) and two-dimensional (2D) NMR techniques and High resolution Fast Atom Bombardment Mass Spectrometry (HRFABMS). Compounds ⁻ were evaluated for their effects on the production of nitric oxide (NO) in Lipopolysaccharide (LPS)-activated mouse peritoneal macrophages.
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