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Utilizing Tissues Self-Assembled in Fiber Optic-Based "Chinese Guzheng Strings" for Contractility Sensing and Drug Efficacy Evaluation: A Practical Approach.
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January 2025
State Key Laboratory of Biocatalysis and Enzyme Engineering, Stem Cells and Tissue Engineering Manufacture Center, School of Life Science, Hubei University, Wuhan, Hubei, 430062, China.
Recent advances in drug design and compound synthesis have highlighted the increasing need for effective methods of toxicity evaluation. A specialized force sensor, known as the light wavelength-encoded "Chinese guzheng" is developed. This innovative sensor is equipped with optical fiber strings and utilizes a wavelength-encoded fiber Bragg grating (FBG) that is chemically etched to reduce its diameter.
View Article and Find Full Text PDFAC Magnetometry Using Nano-ferrofluid Cladded Multimode Interferometric Fiber Optic Sensors for Power Grid Monitoring Applications.
ACS Appl Nano Mater
December 2024
Mechanical Engineering & Materials Science, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
The AC magnetic field response of the superparamagnetic nano-ferrofluid is an interplay between the Neel and Brownian relaxation processes and is generally quantified via the susceptibility measurements at high frequencies. The high frequency limit is dictated by these relaxation times which need to be shorter than the time scale of the time varying magnetic field for the nano-ferrofluid to be considered in an equilibrium state at each time instant. Even though the high frequency response of ferrofluid has been extensively investigated for frequencies up to GHz range by non-optical methods, harnessing dynamic response by optical means for AC magnetic field sensing in fiber-optic-based sensors-field remains unexplored.
View Article and Find Full Text PDFRetinal thinning differentiates treatment effects in relapsing multiple sclerosis below the clinical threshold.
Ann Clin Transl Neurol
December 2024
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Objective: To investigate retinal layer thinning as a biomarker of disease-modifying treatment (DMT) effects in relapsing multiple sclerosis (RMS).
Methods: From an ongoing prospective observational study, we included patients with RMS, who (i) had an optical coherence tomography (OCT) scan within 6 to 12 months after DMT start (rebaseline) and ≥1 follow-up OCT ≥12 months after rebaseline and (ii) adhered to DMT during follow-up. Differences between DMT in thinning of peripapillary-retinal-nerve-fiber-layer (pRNFL) and macular ganglion cell-plus-inner plexiform-layer (GCIPL) were analyzed using mixed-effects linear regression.
Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments.
Photodiagnosis Photodyn Ther
December 2024
Photobiological Dermatology Laboratory Medical Research Centre, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, Spain.
Photodynamic therapy (PDT) light sources must match their emission spectrum with the absorption spectrum of the photosensitizer, provide precise treatment definition, deliver adequate irradiance, avoid thermal damage, and minimize treatment duration. Additionally, they should be adaptable to different photosensitizers, easy to manipulate, and cost-effective. Current LED sources are difficult to customize, rigid, and primarily designed for broad-area treatments.
View Article and Find Full Text PDFTherapeutic role of erythropoietin in methanol induced optic neuropathy: a systematic review.
Daru
November 2024
Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, 5166614766, Iran.
Purpose: Despite various therapeutic attempts, an approved treatment for Methanol-induced optic neuropathy (MION), a sight-threatening disorder, is still lacking. Erythropoietin known as an erythropoietic cytokine, possesses various non-hematopoietic properties that make it a candidate for MION treatment. This systematic review aims to assess the potential therapeutic role of erythropoietin in MION.
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