A novel, electrochemically synthesized, silver nanoparticles (AgNPs) formulation was evaluated against , , , and strains from cystic fibrosis (CF) patients. AgNPs were particularly active against and planktonic cells (median MIC: 1.06 and 2.12 μg/ml, respectively) by a rapid, bactericidal and concentration-dependent effect. AgNPs showed to be particularly effective against and biofilm causing a viability reduction ranging from 50% (1×MIC) to >99.9% (4×MIC). Electron microscopy showed that AgNPs deconstruct extracellular matrix of biofilm, and accumulate at the cell surface causing cell death secondary to membrane damage. Compared to Tobramycin, AgNPs showed comparable, or even better, activity against planktonic and biofilm cells. AgNPs at concentrations effective against and . were not toxic to larvae. Our silver-based formulation might be an alternative to antibiotics in CF patients. Further and studies are warranted to confirm this therapeutic potential.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041389 | PMC |
| http://dx.doi.org/10.3389/fmicb.2018.01349 | DOI Listing |
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