AI Article Synopsis
- Syrian hamster embryonic fibroblasts infected with bovine papillomavirus type 1 can induce tumor formation when injected into hamsters.
- Chromosome analysis of the transformed cells showed various abnormalities, with trisomy 11 being a consistent finding across all examined cells.
- The presence of the extra chromosome 11 is deemed crucial for the tumors to develop in this study's model.
Article Abstract
Syrian hamster embryonic fibroblasts transformed by infection with bovine papillomavirus type 1 cause tumors when inoculated into hamsters. Chromosome examinations revealed several abnormal clones in the transformed fibroblasts and a variety of additional markers in three tumors. Only one aberration, trisomy 11, was present in each cell. The extra chromosome #11, thus, is considered to be essential for tumor formation in this model system.
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| http://dx.doi.org/10.1016/0165-4608(86)90095-6 | DOI Listing |
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