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An exceptionally rare case of a giant parathyroid adenoma with carcinoma-like presentation.
Hormones (Athens)
January 2025
Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Giant parathyroid adenoma (GPA) is an extremely rare cause of primary hyperparathyroidism (PHPT) and may sometimes mimic parathyroid carcinoma (PC). Parathyroid carcinoma is also a very rare entity. Both preoperative and postoperative diagnosis of the two conditions remains a challenge.
View Article and Find Full Text PDFFever of Unknown Origin: A Rare Presentation of Parathyroid Carcinoma.
Cureus
December 2024
General Medicine, All India Institute of Medical Sciences, Nagpur, Nagpur, IND.
Fever of unknown origin (FUO) can be a common manifestation of multiple disease processes like infections, hematological & solid organ malignancies, autoimmune disorders, and autoinflammatory diseases. Endocrine causes of FUO are rare but should be considered in differential diagnosis. We present a case of a 35-year-old female with prolonged on-and-off fever and intermittent vomiting for nine months, where extensive workups for chronic infections, malignancy, and autoimmune conditions initially yielded no definitive diagnosis.
View Article and Find Full Text PDFChapter 8: MANAGEMENT OF AGGRESSIVE FORMS OF PRIMARY HPT: PARATHYROID CARCINOMA AND ATYPICAL PARATHYROID TUMOR.
Ann Endocrinol (Paris)
January 2025
Imaging Department, Nuclear Medicine Service, Gustave Roussy, Université Paris-Saclay, F-94805, Villejuif, France.
Parathyroid carcinoma is extremely rare, affecting 1% of cases of primary hyperparathyroidism. For this reason, management is poorly codified and requires expertise in specialized center. PC is genetically determined in a quarter to a third of cases, notably involving the CDC73 gene coding for parafibromin.
View Article and Find Full Text PDFCase report: Ectopic production of intact parathyroid hormone (iPTH) by malignoma mimicking primary hyperparathyroidism.
Front Oncol
December 2024
Department of Nephrology, St. Georg Hospital, Leipzig, Germany.
Background: Malignant hypercalcemia is usually caused by osteolytic processes of metastases, production of parathormone-related peptide, or secretion of 1,25-dihydroxyvitamin D. Ectopic PTH (parathyroid hormone) production by malignancy is very unusual.
Methods: Case report and review of the literature.
A Case of Primary Hyperparathyroidism With a Hypercalcemic Crisis Resulting in Distinct Bone Mineral Redistribution.
Cureus
October 2024
Department of Nutrition and Metabolism, Tokushima University Graduate School, Tokushima, JPN.
Article Synopsis
- A 66-year-old man experienced a rare hypercalcemic crisis due to primary hyperparathyroidism (PHPT) linked to a benign parathyroid adenoma, presenting with severe fatigue and loss of appetite.* -
- Laboratory tests revealed elevated serum calcium (22.5 mg/dL) and parathyroid hormone (PTH) levels (3100 pg/mL), leading to initial treatment for hypercalcemia.* -
- Following parathyroidectomy, a notable change in bone mineral distribution was observed: decreased cortical bone density while trabecular bone density was preserved or enhanced, reflecting the complex role of PTH in bone metabolism and the importance of monitoring in severe PHPT cases.*
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