Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des--butyl Janadolide and Its Biological Evaluation.

To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide-peptide hybrid, a macrolactonization strategy was explored. We prepared des--butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the -butyl group is necessary for the desired bioactivity.